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  4. Association of Increased Qt Dispersion with Coronary Atherosclerosis in Patients with Aortic Stenosis
 
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Association of Increased Qt Dispersion with Coronary Atherosclerosis in Patients with Aortic Stenosis

Resource
INTERNATIONAL JOURNAL OF CARDIOLOGY v.66 n.3 pp.267-274
Journal
INTERNATIONAL JOURNAL OF CARDIOLOGY
Journal Volume
v.66
Journal Issue
n.3
Pages
267-274
Date Issued
1998
Date
1998
Author(s)
TSAI, CHANG-HER
SU, SHENG-FANG
LEE, TSUNG-MING
URI
http://ntur.lib.ntu.edu.tw//handle/246246/90671
Abstract
Abstract To evaluate correlates between electrocardiographic QT dispersion and coronary atherosclerosis in patients with aortic stenosis before aortic valve replacement, 39 consecutive patients > 40 years old with symptomatic aortic stenosis and coronary diameter narrowing 3 50% measured by digital angiographic study were included. An additional matched group with insignificant coronary lesions (< 50%) consisted of 39 patients for comparisons. Matching by age, sex heart rate and incidence of chest pain resulted in 2 comparable groups with identical baseline characteristics. Preoperative transthoracic echocardiography and electrocardiograms were performed in all subjects. QT dispersion was defined as the difference between maximal and minimal QT interval measurements occurring among any of the 12 leads on a standard electrocardiogram. No subject had fewer than nine measurable leads. There were no significant differences of risk factors of coronary artery disease between the 2 groups. From a conditional multivariate logistic regression analysis, independent predictors of development of coronary artery disease in aortic stenosis were only QTc dispersion (odds ratio = 1.255, P = 0.01). A wide QTc dispersion (3 70 ms) correlated with the presence of angiographically significant coronary artery disease with a sensitivity and specificity of 72% and 79 %. The positive accuracy of having significant coronary artery disease in the presence of QTc dispersion 3 70 ms was 78%. The negative predictive value was 74%. In conclusion, electrocardiographic QTc dispersion may provide important clinical information. A wide QTc dispersion in patients with aortic stenosis is associated with a high incidence of coronary artery disease. These findings warrant further investigation in a large trial.
Type
journal article

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

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開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

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