Alanylglutamine-Enriched Total Parenteral Nutrition Improves Protein Metabolism More Than Branched Chain Amino Acid-Enriched Total Parenteral Nutrition in Protracted Peritonitis
Resource
JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE v.42 n.2 pp.183- 190
Journal
JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE
Journal Volume
v.42
Journal Issue
190
Pages
-
Date Issued
1997
Date
1997
Author(s)
NAKA, SHUJI
SAITO, HIDEAKI
LIN, MING-TSAN
Abstract
Branched chain amino acids (BCAAs) and glutamine are both recommended in catabolic states. The object of this study was to compare the efficacies of alanylglutamine (Ala-Gln)- enriched and BCAA-enriched total parenteral nutrition (TPN) on the protein kinetics in peritonitis. Rats were divided into Ala-Gln and BCAA groups after intraperitoneal implantation of an osmotic pump, delivering a continuous infusion of Escherichia coli. Glutamine composed 30.0% (w/v) of the total amino acids in the Ala-Gln group, and BCAA composed 30.5% (w/v) of the total amino acids in the BCAA group. The two solutions were isocaloric and isonitrogenous. Whole body protein turnover and organ fractional protein synthetic rates (FSR) were measured on days 3 and 5. Serum amino acid levels and mucosal morphology were determined. Ala-Gln group had higher rates of whole body protein turnover, and hepatic FSR on both days. Serum glutamine levels correlated with hepatic and muscle FSR. Ala-Gln TPN group had greater mucosal thickness, numbers of mitoses per crypt, and FSR in distal intestine. Ala- Gln-enriched TPN may be a useful nutritional treatment modality in sepsis.
Type
journal article