https://scholars.lib.ntu.edu.tw/handle/123456789/191773
Title: | Alanylglutamine-Enriched Total Parenteral Nutrition Improves Protein Metabolism More Than Branched Chain Amino Acid-Enriched Total Parenteral Nutrition in Protracted Peritonitis | Authors: | NAKA, SHUJI SAITO, HIDEAKI LIN, MING-TSAN |
Issue Date: | 1997 | Journal Volume: | v.42 | Journal Issue: | 190 | Start page/Pages: | - | Source: | JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE | Abstract: | Branched chain amino acids (BCAAs) and glutamine are both recommended in catabolic states. The object of this study was to compare the efficacies of alanylglutamine (Ala-Gln)- enriched and BCAA-enriched total parenteral nutrition (TPN) on the protein kinetics in peritonitis. Rats were divided into Ala-Gln and BCAA groups after intraperitoneal implantation of an osmotic pump, delivering a continuous infusion of Escherichia coli. Glutamine composed 30.0% (w/v) of the total amino acids in the Ala-Gln group, and BCAA composed 30.5% (w/v) of the total amino acids in the BCAA group. The two solutions were isocaloric and isonitrogenous. Whole body protein turnover and organ fractional protein synthetic rates (FSR) were measured on days 3 and 5. Serum amino acid levels and mucosal morphology were determined. Ala-Gln group had higher rates of whole body protein turnover, and hepatic FSR on both days. Serum glutamine levels correlated with hepatic and muscle FSR. Ala-Gln TPN group had greater mucosal thickness, numbers of mitoses per crypt, and FSR in distal intestine. Ala- Gln-enriched TPN may be a useful nutritional treatment modality in sepsis. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/90828 |
Appears in Collections: | 醫學系 |
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