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  1. NTU Scholars
  2. 醫學院
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Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/192035
Title: Conversion from Mycophenolate Mofetil to Enteric-Coated Mycophenolate Sodium in Stable Maintenance Renal Transplant Patients: Pooled Results from Three International, Multicenter Studies
Authors: Pietruck, F.
Abbud-Filho, M.
Vathsala, A.
Massari, P.U.
Po-Huang, L.
Nashan, B.
李伯皇
Keywords: ACUTE REJECTION;GASTROINTESTINAL COMPLICATIONS;PREVENTION;RECIPIENTS;OUTCOMES
Issue Date: 2007
Journal Volume: v.39
Journal Issue: n.1
Start page/Pages: 103-108
Source: TRANSPLANTATION PROCEEDINGS 
Abstract: 
Background. Mycophenolate mofetil (MMF) is effective in renal transplant patients but concerns remain over its gastrointestinal (GI) tolerability. Enteric-coated mycophenolate sodium (EC-MPS; myfortic) has been developed with the intention of improving mycophenolic acid-related GI tolerability. Methods. Data were pooled in a planned analysis of three subprotocols of the myfortic Prospective Multicenter Study (n7yPROMS). In a 6-month study, efficacy and safety of converting stable renal transplant recipients from MMF to a bioequivalent dose of EC-MPS for mycophenolic acid exposure were evaluated. Treatment efficacy was recorded and graft function was assessed by measuring serum creatinine and estimating creatinine clearance . Adverse events (AEs) and infections were monitored and the incidence of EC-MPS dose changes was recorded. Results. A total of 588 patients were recruited, 564 (96%) of whom completed the study. The rate of treatment failure (defined as biopsy- proven acute rejection, graft loss, or death) was 1.9%, with no episodes of graft loss and only one death reported during the study. Renal function remained stable throughout the trial. EC- MPS was well tolerated; the majority of AEs were mild or moderate in severity. Dose reductions or interruptions were required by 6.3% and 1.9% of patients, respectively. Gastrointestinal AEs occurred in 138 patients( 23.5%). The rate of dose adjustment as a result of a GI AE was 2.2%. Conclusions. Equimolar conversion from MMF to EC- MPS in maintenance renal transplant patients was safe and maintained efficacy.
URI: http://ntur.lib.ntu.edu.tw//handle/246246/91778
Appears in Collections:醫學系

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
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開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

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