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  4. Effects of parenterally infused fat emulsions on cytokines secretion in peritoneal fluid and cytokine – induced metabolic changes in septic rats
 
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Effects of parenterally infused fat emulsions on cytokines secretion in peritoneal fluid and cytokine – induced metabolic changes in septic rats

Date Issued
1999-07-31
Date
1999-07-31
Author(s)
陳維昭
DOI
882314B002276
URI
http://ntur.lib.ntu.edu.tw//handle/246246/24388
Abstract
The effect of preinfusing total parenteral nutrition (TPN) enriched with n-3 or n-6 fatty acids on plasma amino acid profiles, and inflammatory-related mediators was evaluated in septic rats. Thirty -two rats, with internal jugular catheters, were divided into two experimental groups and received TPN. TPN provided 300 kcal/kg/day with 40% of the non-protein energy provided as fat. All TPN solutions were isonitrogenous and identical in nutrient composition except for the fat emulsion, which was made of safflower oil (SO) or fish oil (FO). After receiving TPN for 7days, each experimental group was further divided into control and sepsis subgroups. Septic rats were induced by cecal ligation and puncture, whereas control rats received sham operation. The all rats were classified to four groups as follows: fish oil control group (FOC, n=7), fish oil sepsis group (FOS, n=8), safflower oil control group (SOC, n=8), safflower oil sepsis group (SOS, n=9). The results demonstrated that plasma leucine and isoleucine levels were significantly lower in the SOS group than in the SOC group, whereas no difference in these two amino acids was observed between the FOC and FOS groups. Plasma arginine levels were significantly lower in septic groups than in those without sepsis when either fish oil or safflower oil was infused. Plasma glutamine levels, however, did not differ among all groups. No significant differences in interleukin-1â, interleukin-6, tumor necrosis factor-á, or leukotriene B4 concentrations in peritoneal lavage fluid were observed between the 2 septic groups. These results suggest that, compared with safflower oil, TPN with fish oil emulsion did not have effects on inflammatory-related cytokines or leukotriene in peritoneal lavage fluid. Preinfusion with fish oil emulsion before sepsis, however, ameliorates the catabolic reaction of skeletal muscle in septic rats.
Subjects
total parenteral nutrition
sepsis
fish oil
safflower oil
cytokine
amino
acid pattern
Publisher
臺北市:國立臺灣大學醫學院外科
Type
report
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