人類肝細胞癌侵襲、轉移的分子機轉

Abstract

吾人利用 Western blotting 分析並比 較原發性與復發性肝癌病人檢體中之β- catenin , connexin 43, connexin 32 and Ecadherin 表現。就原發性與復發性肝癌病 人檢體而言，其肝癌部分之β-catenin 與 connexin 43 的表現量較非肝癌部分強， 但是connexin 32 與 E-cadherin 的表現 量則較弱。就肝癌部分而言，β-catenin 與 connexin 43 在復發性肝癌病人檢體的表 現較原發性肝癌病人檢體強，其強度比值 分別為 1.6 與 2.2。然而connexin 32 與 E-cadherin 的表現則無顯著差異。以上之 結果顯示再復發肝癌病人檢體之β- catenin 與connexin 43 的表現量的增加 可能與病人再復發肝癌有關。

The expression levels of β-catenin , connexin 43, connexin 32 and E-cadherin were performed by Western blotting. In primary and recurrent HCC cases, the expression level of β-catenin and connexin 43 in tumorous liver were higher than in non-tumorous liver. But the expression of connexin 32 and E-cadherin were decrease. In tumorous liver, there were significant difference of β-catenin, connexin 43 from recurrent HCC cases and those from primary HCC cases was compared, and the ratio was 1.6 and 2.2. Whereas no significant difference for connexin 32 and E-cadherin express level were observed between primary HCC and recurrent HCC cases. The results indicatedβ-catenin, connexin 43 may play important role in tumorous liver from patients with recurrent HCC.