肝癌組織中生長激素和SOMATOSTATIN接受體分佈之研究

Abstract

本時驗收集60 位肝癌患者手術前及手術後血液及腹腔引流液之標本。分析其中肝細胞生長因子 (hepatocyte growth factor, HGF)、血管內皮生長因子(vascular endothelial growth factor, VEGF)、以及胰島素 生長因子-1(insulin-like growth factor-1, IGF)之濃度。並將這些生長因子之濃度與病人之臨床變數作相關變 數之分析。本實驗發現：在手術前肝癌患者血液中之HGF 和VEGF 濃度較正常人為高。在手術後HGF 和VEGF 有明顯的升高。腹腔引流液中之HGF 和VEGF 也有相同的變化，而且倍術更為明顯。至於IGF 則不論在手術前後或是血液或腹腔引流液中均無明顯的變化。

In this study, we collected and measured the concentrations of hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), and insulin-like growth factor-1 (IGF) in the blood and peritoneal drainage fluid before and after operation. The preoperative concentrations of HGF and VEGF of patients with hepatocellular carcinoma were significantly higher than those of normal control. HGF and VEGF showed postoperative surge after hepatectomy. The change of these concentrations were more significant in the drainage fkuid than that of blood levels. There was no fluctuations of IGF before or after operations. There was no difference between blood and drainage fluid concentrations either.