Effects of L-glutamine supplementation on nutrient metabolism and immune response in thermal injured mice (II)
Date Issued
2003-07-31
Date
2003-07-31
Author(s)
陳維昭
DOI
912314B002329
Abstract
This study investigated the effect of glutamine (GLN) supplementation on
specific antibody production and T lymphocyte distribution in burned mice vaccinated
with detoxified Pseudomonas exotoxin A linked with the outer membrane proteins I
and F, named PEIF. Fifty BALB/c mice were assigned to 2 groups. One group was
fed a control diet with casein as the protein source, while the other group was
supplemented with 4% GLN replaced part of casein. The 2 groups were
isonitrogenous. The mice were immunized twice with PEIF, and the production of
specific antibodies against PEIF was measured every week. After 8 weeks, all mice
received a 30% body surface area burn injury. Mice were sacrificed 24h after the
burn. The distribution of blood T lymphocyte subpopulations and the specific
antibody production were analyzed. The results demonstrated that there were no
significant differences in CD3, CD4 and CD8 T cell populations between the 2 groups
after the burn. The production of specific antibodies against P. aeruginosa
significantly increased in the GLN group at 4 and 7 weeks after immunization, and 24
h after the burn. These results suggest that vaccinating mice with GLN
supplementation may enhance humoral immunity before and after burn injury.
Subjects
burn
T cell population
specific antibody
vaccination
SDGs
Publisher
臺北市：國立臺灣大學醫學院外科
Type
report
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