https://scholars.lib.ntu.edu.tw/handle/123456789/192291
標題: | 雌激素代謝基因多型性與乳癌致癌感受性及療效的關係 | 作者: | 黃俊升 | 關鍵字: | 乳癌;雌激素代謝;aromatase;荷爾蒙受體;基因多形性;致癌感受性;治療;預後;breast cancer;estrogen metabolism;estrogen receptor;genetic polymorphism;cancer susceptibility;treatment;prognosis | 公開日期: | 30-四月-2003 | 出版社: | 臺北市:國立臺灣大學醫學院外科 | 摘要: | 流行病學及細胞生物學研究已確定雌激素與乳癌發生有關。因此,檢測雌激素平衡的 主要變數(包括雌激素的合成、分解代謝及經由雌激素受體調控的組織對雌激素敏感 度)與乳癌致癌危險性的關係極為重要。欲研究雌激素平衡在乳癌發生的角色,不但 需要評估雌激素代謝過程中個人基因型不同而致的不同乳癌致癌感受性,也要了解雌 激素暴露在相關基因與乳癌關聯性上的影響。乳癌的治療包括局部控制與全身性的治 療,全身性治療包括化學治療及荷爾蒙治療。只要病人的癌細胞存有雌激素或黃體素 受體,即應考慮給予荷爾蒙治療。荷爾蒙治療包括如何拮抗荷爾蒙受體或減少病人荷 爾蒙的暴露。後者有在停經婦女aromatase inhibitor 或未停經婦女卵巢切除。此計畫 包含兩部分。第一部份研究是前瞻性對照研究,欲了解雌激素濃度及雌激素受體與代 謝酵素基因型和個人乳癌致癌感受性的關係。吾人已收集300 例乳癌病人白血球及血 漿。第二部份以1989∼2000 年在台大醫院手術治療的500 例原發浸潤性乳癌DNA 為 對象,探討雌激素受體與aromatase 基因多形性與乳癌病人抗雌激素治療療效的關 係。雌激素受體與aromatase 基因型檢測已完成,與療效的關係分析中。 Both epidemiological and cell biology studies have documented the contribution of estrogen to the development of breast cancer. It is, therefore, important to examine the association between the key variables in estrogen homeostasis (i.e., the synthesis and catabolism of estrogen, and the sensitivity of tissue to estrogen operated via estrogen receptor) and the risk of developing breast cancer. A complete understanding of the etiological role of estrogen in breast carcinogenesis will require studies that evaluate both the genes participating in estrogen metabolism and the extent to which estrogen exposure modifies the associations of these genes with breast cancer risk. The treatments of breast cancer include local control and systemic treatments. The latter includes chemotherapy and hormonal therapy. Hormonal therapy is indicated in cancers with the presence of estrogen receptor or progesterone receptor. Hormonal therapy for breast cancer is aimed at antagonizing the hormone receptor or at lowering the level of hormone. This proposal is composed of two parts. The little estrogen produced in postmenopausal women comes predominantly from aromatization of androgens. Aromatase inhibitor can inhibit the conversion. The first part of the study, a prospective case-control study, is aiming at determining whether estrogen level and genotypic polymorphisms of estrogen receptor and estrogen-metabolizing enzymes are associated with individual susceptibility to breast cancer. So far we have collected DNA and plasma bank of 300 cases. The second part of the study, based on our previous clinical data and DNA bank of 500 primary invasive breast cancers operated at the National Taiwan University Hospital from 1989 to 2000, will determine whether genotypic polymorphisms of estrogen receptor and aromatase are related to response to anti-estrogen treatment in breast cancer patients. Genotyping of these specimens has been completed and survival analysis will be done soon. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/24516 | 其他識別: | 913112B002025 | Rights: | 國立臺灣大學醫學院外科 |
顯示於: | 醫學系 |
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913112B002025.pdf | 141.43 kB | Adobe PDF | 檢視/開啟 |
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