Effect of Pravastatin on Left Ventricular Remodeling in CS866-treated Rats with Myocardial Infarction
Date Issued
2004-07-31
Date
2004-07-31
Author(s)
蔡長和
DOI
922314B002229
Abstract
Gap junction remodeling after
infarction appears to be an important feature
of anatomical substrates of ventricular
arrhythmias. Statins have been shown to
reduce post-operation arrhythmias.
However, the involved mechanisms remain
unclear. The present study was to
determine whether the antiarrhythmic effect
of statins is associated with an increased
expression of connexin43 at the border of
infarction. To elucidate the effects, we
conducted experimental infarction in rats and
connexin43 remodeling was investigated by
immunoconfocal and Western blot analysis.
After ligation of the anterior descending
artery, male normocholesterolemic rats were
randomized to either vehicle, pravastatin
treatment, mevalonate, or combination of
pravastatin and mevalonate for 4 weeks.
In contrast to myocytes from the border zone
in the vehicle group, which showed the
amount of Cx43 proteins decreased as
assessed by Western blot, pravastatin-treated
rats showed significantly increased Cx43
immunostaining. Confocal microscopy
confirmed the changes of the junctional
complex. Arrhythmic scores during
programmed stimulation were significantly
higher in the vehicle than those treated with
pravastatin. These beneficial effects of
pravastatin were reversed by the addition of
mevalonate, implicating HMG-CoA
reductase as the relevant target of these drugs.
Subjects
Confocal microscopy
Connexin43
Gap junction
Myocardial
infarction
infarction
Pravastatin
Western blot
Publisher
臺北市：國立臺灣大學醫學院外科
Type
report
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