https://scholars.lib.ntu.edu.tw/handle/123456789/192303
標題: | 乳癌致癌感受性與雄性素受體之基因多型性關連性研究 Breast cancer risk associated with genetic polymorphism of androgen receptor |
作者: | 黃俊升 | 關鍵字: | 乳癌;基因多形性;雄性素受體;致癌感受性;Breast Cancer;genetic polymorphism;susceptibility;androgen receptor | 公開日期: | 31-七月-2004 | 出版社: | 臺北市:國立臺灣大學醫學院外科 | 摘要: | 因個人基因型不同而致的乳癌致癌感受性是近來的研究重點。不同基因型與乳 癌發生相關性的研究,在不同種族常有不同結果,這或許與各族群基因型比例不 同。台灣乳癌好發的年齡層較年輕,亦隱含基因在台灣乳癌的重要角色。雄性素 受體(androgen receptor)可以促進乳房腫瘤的生長與擴散。雄性素基因有一個三核 甘酸重複的部位,其重複的長度因人而異。此基因的多形性與乳癌致癌感受性可 能有關。吾人檢測312 個台灣乳癌的檢體的雄性素受體基因型,並與文獻上的健 康對照組做比較,發現短等位基因的長度在乳癌與健康婦女無差異,但長等位基 因的長度則有顯著差異。若兩等位基因都屬於短等位基因,則罹患乳癌危險性最 低,兩等位基因都為長等位基因,則罹患乳癌危險性最高。吾人的發現顯示雄性 素受體CAG 三核甘酸重複長度多形性與乳癌感受性顯著相關。 Recent attention has brought focus both on genetic predisposition and gene-environmental interaction as susceptibility factors to the development of breast cancer. The ethnic discrepancies in cancer risk associated with various genotypes may be explained in part by the racial difference in the distribution of frequencies of the genotypic polymorphism. Taiwanese breast cancer is characterized by younger age at tumor onset, which suggests that genetic predisposition may be more important in Taiwanese breast cancers than in others. Androgen receptor can mediate breast tumor growth and progression. The androgen-receptor gene AR contains a highly polymorphic CAG trinucleotide repeat in its first exon. Polymorphisms of the AR gene may be susceptibility factors for breast cancer. We investigated the genotypes of CAG repeat in 312 cases of breast cancer in Taiwan and compared the results with those of healthy controls in the literature. The frequency distributions of CAG-repeat lengths in the shorter allele of the case and control were not different, while those in the long allele were significantly different between the case and the control. Women of S/S genotype carries the lowest breast cancer risk and women of L/L carries the highest risk (odds ratio 7.4, 95%CI 3.3-16.5), while women of S/L genotype have breast cancer risk in-between (odds ratio 16.17, 95%CI 7.0-37.3). Our findings suggest the genotype polymorphism of androgen receptor may be a susceptibility factor to breast cancer in Taiwanese women. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/24530 | 其他識別: | 922314B002271 | Rights: | 國立臺灣大學醫學院外科 |
顯示於: | 醫學系 |
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