E-cadherin 基因之promoter 區域(-160 C→A)多型性與大腸 直腸癌致癌危險性的關係
Date Issued
2005-07-31
Date
2005-07-31
Author(s)
梁金銅
DOI
932314B002259
Abstract
A 160℃→A polymorphism in the promoter region of E-cadherin has been
reported to decrease gene transcription. This allelic variation might be a potential
genetic marker for identifying individuals at risk for colorectal cancer. Up to date,
only very few reports were published the regarding clarification of the association
between the polymorphism of E-cadherim and colorectal cancer. A hospital-based
case-control study, including 200 colorectal cancer patients and 200 unaffected
controls, was performed. DNA from peripheral blood samples was examined by
polymerase chain reaction-restriction fragment length polymorphism. Logistic
regression analyses were used to computed odds ratio (OR) and 95% confidence
interval (CI) after adjusted for the influence from diet and life-style factors (e.g. red
meat, smoking, drinking, obesity, and diabetes mellitus ). In 200 healthy Taiwanese,
the distribution of genotype C/C was 42% (n=84), C/A was 48.0% (n=96), and AA
was 10% (n=20). The frequency of variant A/A genotype in colorectal cancer cases (4
of 200, 2%) was significantly lower than that of controls (20 of 200, 10%) (p<0.005),
conferring a 5-hold decrease in the risk of colorectal cancer (OR, 0.20 : 95% CI,
0.06-0.56) compared with the C/C genotype. Stratification of the colorectal cancer
cases according to their location (left-sided vs. right-sided colon), histology (well,
moderate, and poor differentiation), tumor stage (stage 0, Ⅰvs. stageⅡ,Ⅲ,Ⅳ), and
lymph node metastasis(positive and negative) fail to reveal any heterogeneity with resped to E-cadherin genotype. The present data suggest that individuals with
E-cadherin-160 A/A genotype have a decreased risk of colorectal cancer. Further
study is mandatory to clarify the functional relevance of the A allele in vivo and to
confirm the inverse association of the A/A genotype with colorectal cancer in large
epidemiologic studies.
Subjects
E-cadherin
基因多型性
黏著分子
大腸直腸癌
轉移
正位種植
SDGs
Publisher
臺北市：國立臺灣大學醫學院外科
Type
report
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