https://scholars.lib.ntu.edu.tw/handle/123456789/192345
標題: | Heart Transplantation Using Donors Positive for Hepatitis | 作者: | WANG, SHOEI-SHEN CHOU, NAI-KUAN KO, WEN-JE YU, HSI-YU CHEN, YIH-SHARNG HSU, RON-BIN HUANG, SONG-CHEI CHI, NAI-HSIN TSAO, CHUAN-I LAI, MING-YANG LIAU, CHIAU-SUONG LEE, YUAN-THE |
公開日期: | 2004 | 卷: | v.36 | 期: | n.8 | 起(迄)頁: | 2371-2373 | 來源出版物: | TRANSPLANTATION PROCEEDINGS | 摘要: | From May 1994 to September 2003, 177 hearts were procured for heart transplantation (HTx) from donors ranging in age from 1 year 2 months to 66 years 5 months (mean = 30 years). All donors and recipients received serologic tests for hepatitis B surface antigen (HBsAg) and antibody (anti -HBs), and hepatitis C virus antibody (anti-HCV). Thirty-two donors were HBsAg-positive and another four were anti-HCV- positive. Two HBsAg- positive donors were transplanted to patients with no previous evidence of hepatitis. After HTx, one received hepatitis B immunoglobulin prophylaxis and no hepatitis was noted during a 5 years follow-up. The other seroconverted at 4 months after HTx, requiring lamivudine treatment. Another four HBsAg-positive donors were transplanted to HBsAg-positive recipients. All four recipients had hepatitis flare-ups requiring lamivudine treatment. The other 26 HBsAg-positive donors were transplanted to anti-HBs-positive recipients. None suffered from hepatitis. Among the four patients receiving anti-HCV- positive hearts, seroconversion was noted in one recipient at 26 months. This patient never had clinical hepatitis before he died of allograft rejection at 3 years after HTx. The other three recipients remain anti-HCV negative during follow-up of 80, 50 , and 46 months. It was concluded the hepatitis B- or C-positive donors could be used as heart donors for status 1 patients. Donors with positive HBsAg may be transplanted to anti-HBs-positive recipients with no HBV infection. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/91965 |
顯示於: | 醫學系 |
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