Aspirin Inhibits Matrix Metalloproteinase-2 Activity, Increases E- Cadherin Production, and Inhibits in Vitro Invasion of Tumor Cells
Resource
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS v.282 n.3 pp.671- 677
Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Journal Volume
v.282
Journal Issue
677
Pages
-
Date Issued
2001
Date
2001
Author(s)
LEE, PO-HUANG
Abstract
Aspirin (acetylsalicylic acid) is a widely used antiinflammatory drug. Recently, aspirin was shown to reduce the risk of development of cancer and mortality from it. Tumor metastasis is the most important cause of cancer death . The aim of the present study was to investigate if aspirin affects the invasion of cancer cells. Matrix metalloproteinases (MMPs) and cell adhesion molecules play important roles in the modulation of tumor invasion, Gelatin -based zymography assay showed that aspirin inhibited MMP-2 activity of SK-Hep-l cancer cells. Matrigel-based chemoinvasion assay showed that aspirin inhibited in vitro invasion of SK-Hep-l cancer cells. Aspirin treatment also increased the production of the cell adhesion molecule, E- cadherin, in Hep G2 cancer cells. Aspirin is a cyclooxygenase (COX) inhibitor. Treatment of cells with another COX inhibitor, sulindac, also inhibited MIMP-2 activity and increased E- cadherin production of cells. These results indicate that aspirin can modulate both MMP-2 and E -cadherin production and therein may possess antimetastatic effect. (C) 2001 Academic Press.
Subjects
aspirin
cancer
invasion
E-cadherin
matrix metalloproteinase
cyclooxygenase
SDGs
Type
journal article