https://scholars.lib.ntu.edu.tw/handle/123456789/192503
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 外科 | en |
dc.contributor.author | LEE, PO-HUANG | en |
dc.contributor.author | 李伯皇 | zh-tw |
dc.creator | 李伯皇 | zh-tw |
dc.creator | LEE, PO-HUANG | en |
dc.date | 2001 | en |
dc.date.accessioned | 2009-01-08T06:04:40Z | - |
dc.date.accessioned | 2018-07-11T09:30:58Z | - |
dc.date.available | 2009-01-08T06:04:40Z | - |
dc.date.available | 2018-07-11T09:30:58Z | - |
dc.date.issued | 2001 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/96205 | - |
dc.description.abstract | Aspirin (acetylsalicylic acid) is a widely used antiinflammatory drug. Recently, aspirin was shown to reduce the risk of development of cancer and mortality from it. Tumor metastasis is the most important cause of cancer death . The aim of the present study was to investigate if aspirin affects the invasion of cancer cells. Matrix metalloproteinases (MMPs) and cell adhesion molecules play important roles in the modulation of tumor invasion, Gelatin -based zymography assay showed that aspirin inhibited MMP-2 activity of SK-Hep-l cancer cells. Matrigel-based chemoinvasion assay showed that aspirin inhibited in vitro invasion of SK-Hep-l cancer cells. Aspirin treatment also increased the production of the cell adhesion molecule, E- cadherin, in Hep G2 cancer cells. Aspirin is a cyclooxygenase (COX) inhibitor. Treatment of cells with another COX inhibitor, sulindac, also inhibited MIMP-2 activity and increased E- cadherin production of cells. These results indicate that aspirin can modulate both MMP-2 and E -cadherin production and therein may possess antimetastatic effect. (C) 2001 Academic Press. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS v.282 n.3 pp.671- 677 | en |
dc.relation.ispartof | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.subject | aspirin | en |
dc.subject | cancer | en |
dc.subject | invasion | en |
dc.subject | E-cadherin | en |
dc.subject | matrix metalloproteinase | en |
dc.subject | cyclooxygenase | en |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | Aspirin Inhibits Matrix Metalloproteinase-2 Activity, Increases E- Cadherin Production, and Inhibits in Vitro Invasion of Tumor Cells | en |
dc.type | journal article | en |
dc.relation.pages | - | - |
dc.relation.journalvolume | v.282 | - |
dc.relation.journalissue | 677 | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en_US | - |
item.cerifentitytype | Publications | - |
顯示於: | 醫學系 |
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