https://scholars.lib.ntu.edu.tw/handle/123456789/192548
標題: | Effects of Medium-Chain Triglyceride in Parenteral Nutrition on Rats Undergoing Gastrectomy | 作者: | LIN, MING-TSAN 李伯皇 |
關鍵字: | total parenteral nutrition;gastrectomy;MCT/LC, LCT;cytokine;superoxide dismutase (SOD);glutathione peroxidase (GSHPx) | 公開日期: | 2002 | 卷: | v.21 | 期: | n.1 | 起(迄)頁: | 39-43 | 來源出版物: | CLINICAL NUTRITION | 摘要: | This study was designed to investigate the effects of pre- infusion with total parenteral nutrition (TPN) using medium- chain triglyceride (MCT) versus long-chain triglyceride ( LCT) emulsion as fat sources on hepatic lipids, inflammatory mediators and antioxidant capacity in rats undergoing gastrectomy. Rats with internal jugular catheter, were divided into two groups and received TPN. TPN supplied 300 kcal/kg/d with 39% of the energy provided as fat. All TPN solutions were isonitrogenous and identical in nutrient composition except for the fat emulsion, which was composed of MCT/LCT (1:1) or LCT After receiving TPN for 5 days, the rats underwent partial gastrectomy and were sacrificed 24 h after surgery. The results of the study demonstrated that the MCL/LCT group had lower hepatic lipids than did the LCT group. No differences in interleukin-1 beta interleukin-6 and tumor necrosis factor-alpha in peritoneal lavage fluid were observed between the two groups. Erythrocyte glutathione peroxidase activity was significantly higher in the LCT group than the MCT/LCT group, although erythrocyte superoxide dismutase activity did not differ significantly between the two groups. These results suggest that infusion with MCT/LCT before an abdominal operation did not have an effect on modulating the production of inflammatory mediators in the location of the injurious stimulus. However , pre-infusion with MCT/LCT have beneficial effect in improving liver lipid metabolism and reducing oxidative stress in rats with gastrectomy. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/96250 |
顯示於: | 醫學系 |
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