https://scholars.lib.ntu.edu.tw/handle/123456789/192596
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 外科 | en |
dc.contributor.author | LIANG, JIN-TUNG | en |
dc.contributor.author | 鄭安理 | zh_TW |
dc.creator | 梁金銅;黃國晉;鄭安理;鄭永銘;吳明賢;王世名 | zh_TW |
dc.creator | LIANG, JIN-TUNG;HUANG, KUO-CHIN;CHENG, ANN-LII;JENG, YUNG-MING;WU, MING-SHIANG;WANG, SHIH-MING | en |
dc.date | 2003 | en |
dc.date.accessioned | 2009-01-08T06:19:47Z | - |
dc.date.accessioned | 2018-07-11T09:35:42Z | - |
dc.date.available | 2009-01-08T06:19:47Z | - |
dc.date.available | 2018-07-11T09:35:42Z | - |
dc.date.issued | 2003 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/96298 | - |
dc.description.abstract | Background: The aim of the present study was to identify the clinicopathological and molecular biological characteristics of early- onset colorectal cancers. Methods: The clinicopathological and molecular biological parameters of 138 consecutive patients with colorectal cancer aged less than 40 years were compared with those of 339 patients aged 60 years or more. Results: The younger patients with colorectal cancer had more mucin-producing (14.5 versus 4.7 per cent; P < 0.001) and poorly differentiated (7.2 versus 3 .3 per cent; P = 0.015) tumours, a higher incidence of synchronous (5.8 versus 1.2 per cent; P = 0.007) and metachronous (4.0 versus 0.6 per cent; P = 0.023) colorectal cancers, and more advanced tumour stage (P < 0.001) than older patients. The operative mortality rate was lower (0.7 versus 5.0 per cent; P = 0.026), and cancer- specific survival was similar (in stage I, II and III disease; P > 0. 05) or better (in stage IV disease; 95 per cent confidence interval 22.50 to 28.41 versus 12.61 to 17.05 months; P < 0. 001). There was a higher percentage of normal p53 expression(61.1 versus 46.8 percent; P = 0.023) and high- frequency microsatellite instability (MSI-H) (29.4 versus 6. 3 per cent; P < 0.001), and a similar family history of cancer (17.5 versus 14.2 per cent; P > 0.05), compared with older patients. Conclusion: Young patients with colorectal. cancer have several distinct clinicopathological and molecular biological features. The mechanisms underlying the inconsistency between the presence of MSI-H and a family history of cancer in these early-onset colorectal cancers deserve further investigation. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | BRITISH JOURNAL OF SURGERY v.90 n.2 pp.205-214 | en |
dc.relation.ispartof | BRITISH JOURNAL OF SURGERY | - |
dc.subject | PLUS LEUCOVORIN CHEMOTHERAPY | en |
dc.subject | PALLIATIVE BOWEL RESECTION | en |
dc.subject | DNA- REPLICATION ERROR | en |
dc.subject | MICROSATELLITE INSTABILITY | en |
dc.subject | YOUNG-PATIENTS | en |
dc.subject | CURATIVE RESECTION | en |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | Clinicopathological and Molecular Biological Features of Colorectal Cancer in Patients Less Than 40 Years of Age | en |
dc.type | journal article | en |
dc.relation.pages | 205-214 | - |
dc.relation.journalvolume | v.90 | - |
dc.relation.journalissue | n.2 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。