https://scholars.lib.ntu.edu.tw/handle/123456789/192634
標題: | Effects of Glutamine Supplementation on Innate Immune Response in Rats with Gut-Derived Sepsis | 作者: | YEH, SUNG-LING LAI, YU-NI SHANG, HUEY- FANG LIN, MING-TSAN |
關鍵字: | glutamine;gut-derived sepsis;phagocytosis;lymphocyte subpopulation | 公開日期: | 2004 | 卷: | v.91 | 期: | n.3 | 起(迄)頁: | 423-429 | 來源出版物: | BRITISH JOURNAL OF NUTRITION | 摘要: | The present study examined the effect of glutamine (Gln)- enriched diets before sepsis or Gln-containing total parenteral nutrition (TPN) after sepsis, or both, on the phagocytic activity and blood lymphocyte subpopulation in rats with gut-derived sepsis. Rats were assigned to a control group or one of four experimental groups. The control group and groups 1 and 2 were fed a semipurified diet; groups 3 and 4 had part of casein replaced by Gin. After feeding the diets for 10 d, sepsis was induced by caecal ligation and puncture (CLP); TPN was maintained for 3 d after CLP. The control group and groups 1 and 3 were infused with conventional TPN and groups 2 and 4 were supplemented with Gin in the TPN solution. All rats were killed 3 d after CLP or sham operation to examine their immune responses. The results showed that compared with the control group, the phagocytic activities of peritoneal macrophages were enhanced in groups 3 and 4, but not in groups 1 and 2. The proportion of CD3(+) cells in group 1 was significantly lower (P<0.05) than that of the control group, whereas no differences were observed among the control and Gln- supplemented groups. The CD4(+) cell proportion was significantly lower (P <0.05) in group I compared with the control group and groups 3 and 4. These findings suggest that Gln-enriched diets before CLP significantly enhanced peritoneal macrophage phagocytic activity, preserved CD4(+) cells and maintained blood total T lymphocytes in gut-derived sepsis. However, parenteral Gin administration after caecal ligation and puncture had no favourable effects on modulating immune response in septic rats. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/96336 |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。