https://scholars.lib.ntu.edu.tw/handle/123456789/193139
標題: | Proliferative Activity, Apoptosis and Expression of Oestrogen Receptor and Bcl-2 Oncoprotein in Canine Mammary Gland Tumours | 作者: | CHANG, KING-JEN | 關鍵字: | apoptosis;Bcl-2 oncoprotein;cell proliferation;dog;mammary tumour;oestrogen receptor | 公開日期: | 2006 | 卷: | v.134 | 期: | n.1 | 起(迄)頁: | 70-79 | 來源出版物: | JOURNAL OF COMPARATIVE PATHOLOGY | 摘要: | Samples of 39 canine mammary gland tumours (MGTs) were examined immunohistochemically for oestrogen receptor (ER- alpha), Bcl-2 protein and Ki67 antigen, and by TUNEL assay for apoptosis. ER-alpha was expressed by 80% (31/39) of the tumours, including all of the 15 benign tumours and 67% (16/ 42) of the malignant tumours. ER-alpha expression was greater in the benign than in the malignant tumours (P < 0. 01). Bcl-2 protein was detected in 62% (24/39) of the MGTs, of which 67% (10/15) were benign and 58% (14/24) malignant. No significant difference in Bcl-2 expression between benign and malignant tumours was detected. The Ki67 and TUNEL indices were greater in malignant than in benign tumours (P < 0.01). Correlation analysis suggested that ER-a and Bcl-2 expression were related , but this observation lacked statistical significance. The levels of cell proliferation and apoptosis did not appear to be significantly correlated with the expression of Bcl-2. A positive relationship was apparent between cell proliferation and apoptosis, whilst a negative correlation between ER-a and cell proliferation was demonstrated. In conclusion, the suggestion of a positive correlation between ER-alpha and Bcl-2 in canine MGTs indicates that ER may be the regulator of Bcl-2 protein, as in human breast cancer. In contrast to cell proliferation and apoptosis, ER-a and Bcl-2 expression were greater in benign MGTs than in their malignant counterparts. (c) 2005 Elsevier Ltd. All rights reserved. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/92880 |
顯示於: | 醫學系 |
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