https://scholars.lib.ntu.edu.tw/handle/123456789/193150
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 外科 | en |
dc.contributor.author | CHEN, JIN-CHERNG | en |
dc.contributor.author | CHEN, YUN | en |
dc.contributor.author | WU, JIANN-MING | en |
dc.contributor.author | SU, YEN-HAO | en |
dc.contributor.author | TAI, KUO-FENG | en |
dc.contributor.author | TSENG, SHENG-HONG | en |
dc.creator | 陳金城;陳芸;吳建明;蘇彥豪;戴國峰;曾勝弘 | zh-tw |
dc.creator | CHEN, JIN-CHERNG;CHEN, YUN;WU, JIANN-MING;SU, YEN-HAO;TAI, KUO-FENG;TSENG, SHENG-HONG | en |
dc.date | 2006 | en |
dc.date.accessioned | 2009-09-28T02:51:10Z | - |
dc.date.accessioned | 2018-07-11T09:58:24Z | - |
dc.date.available | 2009-09-28T02:51:10Z | - |
dc.date.available | 2018-07-11T09:58:24Z | - |
dc.date.issued | 2006 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/92891 | - |
dc.description.abstract | Purpose: We investigated granulocyte-macrophage colony- stimulating factor (GM-CSF) and interleukin-12 (IL-12) infused into the injection site of irradiated tumor vaccine( TV) as therapy for gliomas. Methods: Rats with subcutaneous RT-2 gliomas were treated with irradiated TV and/or subcutaneous infusion of GM-CSF and/or IL-12 via osmotic minipump 5 days after tumor-cell inoculation. Cytotoxic T lymphocyte (CTL) and natural killer (NK) cell activity were analyzed to investigate immune responses. Rats with intracerebral gliomas were treated with irradiated TV and infused GM-CSF/IL-12 3 days after tumor-cell inoculation. Tumor growth rates and animal survival were followed. Survivors were re-challenged with wild-type RT-2 cells subcutaneously or intracerebrally to study long-term anti- tumor immunity. Results: Rats with subcutaneous gliomas treated with GM-CSF and IL-12 or TV plus GM-CSF or IL-12 did not have increased survival rate (P > 0.2), but did have prolonged survival time (P < 0.05); in contrast, rats treated with TV plus GM-CSF/IL-12 had increased survival rate (P < 0.05) and prolonged survival time (P < 0.05) compared with controls. These treatment strategies showed enhanced CTL and NK cell activities. Rats with intra- cerebral gliomas treated with TV plus GM-CSF/ IL-12 did not have increased survival rate (P=0.11), but did have prolonged survival time (P < 0.0001). Survivors in each group were re- challenged with wild-type RT-2 cells, and all had long-term survival. Conclusions: Irradiated TV plus continuous localized infusion of GM-CSF/IL -12 may induce a tumor-specific anti-tumor immune response on established subcutaneous or intra-cerebral gliomas, and such a treatment strategy deserves consideration as adjuvant treatment for glioma. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | CANCER IMMUNOLOGY IMMUNOTHERAPY v.55 n.7 pp.873-883 | en |
dc.relation.ispartof | CANCER IMMUNOLOGY IMMUNOTHERAPY | - |
dc.subject | glioma | en |
dc.subject | immunotherapy | en |
dc.subject | GM-CSF | en |
dc.subject | IL-12 | en |
dc.subject | tumor vaccine | en |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | Effects of Irradiated Tumor Vaccine and Infusion of Granulocyte- Macrophage Colony-Stimulating Factor and Interleukin-12 on Established Gliomas in Rats | en |
dc.type | journal article | en |
dc.relation.pages | 873-883 | - |
dc.relation.journalvolume | v.55 | - |
dc.relation.journalissue | n.7 | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en_US | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
顯示於: | 醫學系 |
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