https://scholars.lib.ntu.edu.tw/handle/123456789/193165
標題: | Initial Experience with Abo-Incompatible Live Donor Renal Transplantation | 作者: | TSAI, MENG-KUNG WU, MING-SHIOU 蔡孟昆 |
關鍵字: | ABO blood type;renal transplantation | 公開日期: | 2006 | 卷: | v.105 | 期: | n.9 | 起(迄)頁: | 775-779 | 來源出版物: | JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION | 摘要: | The serious shortage of cadaveric organs has prompted the development of ABO-incompatible live donor renal transplantation. We report our experience of the initial two live donor ABO incompatible renal transplants at our hospital. The first patient was a 55-year-old type A female who received a kidney from her AB type husband. The second patient was a 27-year-old type O male who received renal transplantation from his type A father. Preconditioning immunosuppressive therapy in the two patients with tacrolimus, mycophenolate mofetil and methylprednisolone was started 7 days before transplantation. During the period of preconditioning, double filtration plasmapheresis (DFPP) was employed to remove anti-A and -B antibodies. Laparoscopic splenectomy and renal transplantation were performed after the anti-donor ABO antibodies were reduced to a titer of 1:4. Rituximab, a humanized monoclonal anti-CD 20 antibody, was administered to the second patient due to a rebound in the anti-A antibody titer during the preconditioning period. Under a tacrolimus-based immunosuppressive regimen, both patients recovered very well without any evidence of rejection. Serum creatinine levels were 1.0 and 1.4 mg/dL at 6 and 3 months after transplantation, respectively. These cases illustrate that with new immunosuppressive agents, DFPP and splenectomy, ABO -incompatible renal transplantation can be successfully conducted in end-stage renal disease patients whose only available live donors are blood group incompatible. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/92906 |
顯示於: | 醫學系 |
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