|Title:||Annexin A4: A Novel Molecular Marker for Gastric Cancer with Helicobacter Pylori Infection Using Proteomics Approach||Authors:||LIN, LI-LING
|Keywords:||2-DE;annexin A4;gastric cancer;helicobacter pylori;tructure modeling||Issue Date:||2008||Journal Volume:||2||Journal Issue:||4||Start page/Pages:||619-634||Source:||PROTEOMICS-CLINICAL APPLICATIONS||Abstract:||
Helicobacter pylori was reported to be an important risk factor for the carcinogenesis of gastric cancer. Here, we used a proteomic approach to find differentially expressed proteins between the normal and tumor tissue of gastric cancer patients infected with H. pylori. In our results, we found annexin A4 was over-expressed in patients infected with H. pylori and was found in tumor cells, and over- expressed in gastric cancer SCM-1 cells after H. pylori infection. Ca2+ can be induced by H. pylori and interact with annexin A4 Ca2+ binding site to block the calmodulin- activated chloride conductance activation; therefore, it produces a new environment that benefits the malignant existence of H. pylori and raises the risk for gastric cancer. We also found interleuken-8 (IL-8) expression levels were increased in H. pylori infected SCM-1 cells. Combined with previous reports and our results, we summarize that the over-expression of annexin A4 in SCM-1 cells with H. pylori infection may subsequently induce IL-8 which can further cause tumor angiogenesis. In this paper, we show that annexin A4 is a potential novel molecular marker for gastric cancer with H. pylori infection, and our results may provide a new insight in the development of new anti-cancer drugs.
|Appears in Collections:||醫學系|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.