DC 欄位 | 值 | 語言 |
dc.contributor | 外科 | en |
dc.contributor.author | Lin, Li-Ling | en_US |
dc.contributor.author | CHIUNG-NIEN CHEN | en_US |
dc.contributor.author | WEI-CHOU LIN | en_US |
dc.contributor.author | PO-HUANG LEE | en_US |
dc.contributor.author | KING-JEN CHANG | en_US |
dc.contributor.author | YO-PING LAI | en_US |
dc.contributor.author | JIN-TOWN WANG | en_US |
dc.contributor.author | HSUEH-FEN JUAN | en_US |
dc.creator | 林俐伶;陳炯年;林維洲;李伯皇;張金堅;賴祐平;王錦堂;阮雪芬 | zh-tw |
dc.creator | LIN, LI-LING;CHEN, CHIUNG-NIEN;LIN, WEI -CHOU;LEE, PO-HUANG;CHANG, KING-JEN;LAI, YO-PING;WANG, JIN-TOWN;JUAN, HSUEH-FEN | en |
dc.date | 2008 | en |
dc.date.accessioned | 2009-12-18T02:26:49Z | - |
dc.date.accessioned | 2018-07-11T09:59:17Z | - |
dc.date.available | 2009-12-18T02:26:49Z | - |
dc.date.available | 2018-07-11T09:59:17Z | - |
dc.date.issued | 2008 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/174628 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw/bitstream/246246/174628/1/000007.pdf | - |
dc.description.abstract | Helicobacter pylori was reported to be an important risk factor for the carcinogenesis of gastric cancer. Here, we used a proteomic approach to find differentially expressed proteins between the normal and tumor tissue of gastric cancer patients infected with H. pylori. In our results, we found annexin A4 was over-expressed in patients infected with H. pylori and was found in tumor cells, and over- expressed in gastric cancer SCM-1 cells after H. pylori infection. Ca2+ can be induced by H. pylori and interact with annexin A4 Ca2+ binding site to block the calmodulin- activated chloride conductance activation; therefore, it produces a new environment that benefits the malignant existence of H. pylori and raises the risk for gastric cancer. We also found interleuken-8 (IL-8) expression levels were increased in H. pylori infected SCM-1 cells. Combined with previous reports and our results, we summarize that the over-expression of annexin A4 in SCM-1 cells with H. pylori infection may subsequently induce IL-8 which can further cause tumor angiogenesis. In this paper, we show that annexin A4 is a potential novel molecular marker for gastric cancer with H. pylori infection, and our results may provide a new insight in the development of new anti-cancer drugs. | en_US |
dc.language | en-us | en |
dc.language.iso | en_US | en_US |
dc.relation | PROTEOMICS CLINICAL APPLICATIONS v.2 n.4 pp.619-634 | en_US |
dc.relation.ispartof | Proteomics - Clinical Applications | en_US |
dc.subject | 2-DE | en_US |
dc.subject | annexin A4 | en_US |
dc.subject | gastric cancer | en_US |
dc.subject | helicobacter pylori | en_US |
dc.subject | tructure modeling | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | calcium ion; calmodulin; chloride; interleukin 8; lipocortin 2; lipocortin 4; molecular marker; amino acid sequence; article; binding site; cancer cell; cancer patient; cancer risk; chloride conductance; clinical article; controlled study; cytokine release; gastrectomy; Helicobacter infection; Helicobacter pylori; human; human cell; human tissue; immunohistochemistry; matrix assisted laser desorption ionization time of flight mass spectrometry; nonhuman; priority journal; protein analysis; protein expression; protein protein interaction; protein structure; proteomics; stomach cancer; stomach carcinogenesis; tandem mass spectrometry; tumor vascularization; two dimensional electrophoresis; Western blotting; Helicobacter pylori | - |
dc.title | Annexin A4: A Novel Molecular Marker for Gastric Cancer with Helicobacter Pylori Infection Using Proteomics Approach | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1002/prca.200780088 | - |
item.fulltext | with fulltext | - |
item.grantfulltext | open | - |
dc.relation.pages | 619-634 | en_US |
dc.relation.journalvolume | 2 | en_US |
dc.relation.journalissue | 4 | en_US |
dc.identifier.uri.fulltext | http://ntur.lib.ntu.edu.tw/bitstream/246246/174628/1/000007.pdf | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.fulltext | with fulltext | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Pathology | - |
crisitem.author.dept | Pathology-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Microbiology | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Molecular and Cellular Biology | - |
crisitem.author.dept | Life Science | - |
crisitem.author.dept | Genome and Systems Biology Degree Program | - |
crisitem.author.dept | Office of Research and Development | - |
crisitem.author.orcid | 0000-0003-1192-5220 | - |
crisitem.author.orcid | 0000-0003-2857-3479 | - |
crisitem.author.orcid | 0000-0001-5831-035X | - |
crisitem.author.orcid | 0000-0001-9811-3422 | - |
crisitem.author.orcid | 0000-0002-9904-8199 | - |
crisitem.author.orcid | 0000-0002-1595-6801 | - |
crisitem.author.orcid | 0000-0003-4876-3309 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | Administrative Unit | - |
顯示於: | 醫學系
|