大白鼠精囊血清素系統之探討
Date Issued
2002
Date
2002
Author(s)
謝汝敦
DOI
902314B002449
Abstract
Using our established animal model by stimulating the LSN and monitoring the rat
seminal vesicle, we evaluated some of the subtypes of serotonergic agonists including
8-OH-DPAT (1A), 5-Nonyloxytryptamine (1B), BW723C86 (2B) and MK 212 (2C).
Mature male Wistar rats (12-14 weeks) were used in this study. All of these test drugs
from 10-6 to 10-4 M/kg were injected cumulatively via the catheter of femoral artery.
The phasic tension (ΔmmHg) of each drug at different concentration will be
compared to the control to obtain the dose-response curve of each subtype of 5-HT
agonist. From the dose-response curve, only 8-OH-DPAT (5-HT1A) had a
dose-dependent inhibition on the seminal vesicle pressure response to the LSN
stimulation. More than 50% of inhibition was noted at the concentration of 104 M/kg
of 8-OH-DPAT, and the IC50 of 8-OH-DPAT was 6.46 x 10-5 M/kg.
We believed that 8-OH-DPAT (5-HT1A) mediates the rat seminal vesicle
contraction, not like 5-HT2C receptors in the spinal cord reflex center. However,
further investigation, as immuno-histochemical study is necessary to prove it.
Publisher
臺北市：國立臺灣大學醫學院泌尿科
Type
other
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