|Title:||Use of Dimethylsulfoxide in the Treatment of Interstitial Cystitis
利用 膀胱內灌注Dimethylsulfoxide (DMSO) 來治療間質性膀胱炎的病人
|Issue Date:||1994||Journal Volume:||v.5||Journal Issue:||n.3||Start page/Pages:||157-162||Source:||JOURNAL OF THE UROLOGICAL ASSOCIATION OF R.O.C||Abstract:||
A prospective study was conducted to evaluate the efficacy of intravesical dimethylsul-foxide (DMSO) in the treatment of patients with interstitial cystitis (IC). Nighteen female patients with clinical evidences suggestive of IC received intravesicat instillation of 50ml 50% DMSO every two weeks for six sessions. Response was assessed subjectively and urodynamically. Of the 15 patients completing this study, the subjective improvement rate was 53.3% (8/15). DMSO treatment caused a significant decrease in voiding frequency (16.9±6.1 vs. 19.7±4.8, p<0.05 ) and an increase of voided volume (136.9 ± 40.1 ml vs. 107.4 ±35.9 ml, p<0.05), but not of first sensation of filling (119 .5 ± 19.9 ml vs. 112. 7 ± 20.7 ml, p>0.05) and cystometric bladder capacity (240.0 ± 54.1 ml vs. 227.9 ± 51.5 ml, p>0 .05). Side effects included six instances of local irritation and one headache. The follow-up was 6 to 20 months, with 6 of the responders requiring further intermittent instillations of DMSO. Eventually, four of them failed to respond to DMSO instillation and other treatments were resorted to. From this study, it was concluded that shile intavesicular DMSO can help patients with IC in short- term follow-up, patients gradually become refractory to this type of therapy.#0085#
|Appears in Collections:||醫學系|
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