Use of Dimethylsulfoxide in the Treatment of Interstitial Cystitis
Resource
JOURNAL OF THE UROLOGICAL ASSOCIATION OF R.O.C. v.5 n.3 pp.157-162
Journal
JOURNAL OF THE UROLOGICAL ASSOCIATION OF R.O.C
Journal Volume
v.5
Journal Issue
n.3
Pages
157-162
Date Issued
1994
Date
1994
Author(s)
YU, HONG-JENG
CHIU, TSU-YIH
LAI, MING-KUEN
Abstract
A prospective study was conducted to evaluate the efficacy of intravesical dimethylsul-foxide (DMSO) in the treatment of patients with interstitial cystitis (IC). Nighteen female patients with clinical evidences suggestive of IC received intravesicat instillation of 50ml 50% DMSO every two weeks for six sessions. Response was assessed subjectively and urodynamically. Of the 15 patients completing this study, the subjective improvement rate was 53.3% (8/15). DMSO treatment caused a significant decrease in voiding frequency (16.9±6.1 vs. 19.7±4.8, p<0.05 ) and an increase of voided volume (136.9 ± 40.1 ml vs. 107.4 ±35.9 ml, p<0.05), but not of first sensation of filling (119 .5 ± 19.9 ml vs. 112. 7 ± 20.7 ml, p>0.05) and cystometric bladder capacity (240.0 ± 54.1 ml vs. 227.9 ± 51.5 ml, p>0 .05). Side effects included six instances of local irritation and one headache. The follow-up was 6 to 20 months, with 6 of the responders requiring further intermittent instillations of DMSO. Eventually, four of them failed to respond to DMSO instillation and other treatments were resorted to. From this study, it was concluded that shile intavesicular DMSO can help patients with IC in short- term follow-up, patients gradually become refractory to this type of therapy.#0085#