https://scholars.lib.ntu.edu.tw/handle/123456789/193611
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 泌尿科 | en |
dc.contributor.author | PU, YEONG-SHIAU | en |
dc.contributor.author | HOUR, TZYH-CHYUAN | en |
dc.contributor.author | CHUANG, SHUANG-EN | en |
dc.contributor.author | CHENG, ANN-LII | en |
dc.contributor.author | LAI, MING-KUEN | en |
dc.contributor.author | KUO, MIN-LIANG | en |
dc.contributor.author | 鄭安理 | zh-tw |
dc.creator | 蒲永孝;侯自銓;莊雙恩;鄭安理;賴明坤;郭明良 | zh-tw |
dc.creator | PU, YEONG-SHIAU;HOUR, TZYH-CHYUAN;CHUANG, SHUANG-EN;CHENG, ANN-LII;LAI, MING-KUEN;KUO, MIN-LIANG | en |
dc.date | 2004 | en |
dc.date.accessioned | 2009-01-16T03:14:51Z | - |
dc.date.accessioned | 2018-07-11T17:08:56Z | - |
dc.date.available | 2009-01-16T03:14:51Z | - |
dc.date.available | 2018-07-11T17:08:56Z | - |
dc.date.issued | 2004 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/97160 | - |
dc.description.abstract | BACKGROUND. Interleukin (IL)-6-mediated anti-apoptotic effects and drug- resistance mechanisms in prostate cancer cells were investigated. METHODS. IL-6 levels of PC-3 and LNCaP cells were studied by using ELISA. Protective effects of IL-6 on cytotoxic agent-induced apoptosis were studied by exogenous IL-6 in serum-starved PC-3 cells and by anti- sense IL-6 strategy. Western blotting and reverse transcription-polymerase chain reaction (RT-PCR) were used to determine IL-6 effects on Bcl-2 family proteins. Tetracycline-regulated Bcl-xL expression system and dominant negative STAT3 transfectants were used to study IL-6 signaling pathways and its anti-apoptosis effects. RESULTS. Exogenous IL-6 and anti-sense IL- 6 oligonucleotide treatment conferred resistance to cytotoxic agent- induced apoptosis. Among Bcl-2 family proteins, only Bcl-xL was evidently increased by IL-6 stimulation. The anti-apoptotic effect of IL-6 can be significantly attenuated by anti-sense bcl-xL transfection and partially abrogated in dominant negative STAT3 transfectants. CONCLUSIONS. IL-6 is a survival factor against cytotoxic agent-induced apoptosis through both STAT3 and bcl-xL pathways in prostate cancer cells. Prostate 60: 120-129, 2004. (C) 2004 Wiley-Liss, Inc. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | PROSTATE v.60 n.2 pp.120-129 | en |
dc.relation.ispartof | PROSTATE | - |
dc.subject | cytotoxic agents | en |
dc.subject | apoptosis | en |
dc.subject | prostatic neoplasms | en |
dc.subject | Bcl-xL | en |
dc.subject | STAT3 | en |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | Interleukin-6 Is Responsible for Drug Resistance and Anti-Apoptotic Effects in Prostatic Cancer Cells | en |
dc.relation.pages | 120-129 | - |
dc.relation.journalvolume | v.60 | - |
dc.relation.journalissue | n.2 | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
item.fulltext | no fulltext | - |
顯示於: | 醫學系 |
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