|Title:||Antioxidant Xanthone Derivatives Induce Cell Cycle Arrest and Apoptosis and Enhance Cell Death Induced by Cisplatin in Ntub1 Cells Associated with Ros||Authors:||CHENG, JEN-HAO
|Keywords:||Xanthone;Antioxidation;Cytotoxicity;Reactive oxygen species||Issue Date:||2011||Journal Volume:||v.46||Journal Issue:||n.4||Start page/Pages:||1222-1231||Source:||EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY||Abstract:||
In an effort to develop novel antioxidant as anticancer agents, a series of xanthones were prepared. In vitro screening, the synthetic xanthones revealed significant inhibitory effects on xanthine oxidase and ABTS radical- cation scavenging activity. The selective compounds 2 and 8 induced an accumulation of NTUB1 cells in the G1 phase arrest and cellular apoptosis by the increase of ROS level. The combination of cisplatin and 2 significantly enhanced the cell death in NTUB1 cells. Compounds 2 and 8 did not show cytotoxic activity in selected concentrations against SV-HUC1 cells. The present results suggested that antioxidants 2 and 8 may be used as anticancer agent for enhancing the therapeutic efficacy of anticancer agents and to reduce their side effect.
|Appears in Collections:||醫學系|
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