|Title:||Proinflammatory Cytokine Reactions in Enterovirus 71 Infections of the Central Nervous System||Authors:||CHANG, LUAN-YIN||Issue Date:||2003||Journal Volume:||v.36||Journal Issue:||n.3||Start page/Pages:||269-274||Source:||CLINICAL INFECTIOUS DISEASES||Abstract:||
Enterovirus 71 (EV71) infection can lead to devastating clinical outcomes . An appreciation of the scientific relationship between cytokine response and patient mortality may help limit the risks posed by this deadly illness. We present the results of a study that compared the cerebrospinal fluid (CSF) and serum levels of interleukin-6( IL-6) and interleukin-1β (IL-1β) in 24 patients with EV71 infection. Cases in this study involved diverse manifestations or complications, including encephalitis, poliomyelitis-like syndrome, meningitis, and pulmonary edema . CSF levels of IL-6 in study patients were found to be consistently higher during the first 2 days of central nervous system (CNS) involvement than afterward. Compared with patients who did not have pulmonary edema, patients who experienced pulmonary edema had dramatically varied blood values, including IL-6, white blood cell counts, and glucose levels. Our findings suggest that the combination of CNS and systemic inflammatory response may trigger EV71-related cardiopulmonary collapse.
|Appears in Collections:||醫學系|
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