https://scholars.lib.ntu.edu.tw/handle/123456789/194340
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 小兒科 | en |
dc.contributor.author | NI, YEN-HSUAN | en |
dc.contributor.author | CHANG, MEI-HWEI | en |
dc.contributor.author | CHEN, PEI -JER | en |
dc.contributor.author | TSAI, KEH-SUNG | en |
dc.contributor.author | HSU, HONG-YUAN | en |
dc.contributor.author | CHEN, HUEY-LING | en |
dc.contributor.author | TSUEI, DAW-JEN | en |
dc.contributor.author | CHEN, DING-SHINN | en |
dc.contributor.author | 蔡克嵩 | zh-tw |
dc.creator | 倪衍玄;張美惠;陳培哲;蔡克嵩;許宏遠;陳慧玲;崔道貞;陳定信 | zh-tw |
dc.creator | NI, YEN-HSUAN;CHANG, MEI-HWEI;CHEN, PEI -JER;TSAI, KEH-SUNG;HSU, HONG-YUAN;CHEN, HUEY-LING;TSUEI, DAW-JEN;CHEN, DING-SHINN | en |
dc.date | 2007 | en |
dc.date.accessioned | 2008-12-05T04:14:27Z | - |
dc.date.accessioned | 2018-07-11T17:48:46Z | - |
dc.date.available | 2008-12-05T04:14:27Z | - |
dc.date.available | 2018-07-11T17:48:46Z | - |
dc.date.issued | 2007 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/88629 | - |
dc.description.abstract | Background & Aims: This study investigated the viremia profiles in children with chronic hepatitis B virus (HBV) infection and spontaneous heptitis B e antigen (HBeAg) seroconversion. Methods: Fifty-eight children with chronic HBV infection met the following criteria: normal alanine aminotransferase (ALT) level at enrollment, followed up for more than 10 years, no antiviral treatment, and having under -gone spontaneous HBeAg seroconversion during fol-low-up evaluation. They were grouped according to the post-HBeAg seroconversion HBV-DNA levels: (1) low viremia: transient or never 10 4 copies/mL or greater (n=35) (2) fluctuating high viremia: 104 copies/mL or greater at least twice at intrervals more than 1 year apart (n=23). Abdominal sonography, ALT, and HBV-DNA levels were assessed annually. Another 14 nonseroconverted children served as controls . The precore mutant (nt1896) and genotypes were examined. Results: The initial HBV-DNA level of the 58 serovonverters was 108.4±1.0 copies/mL and decreased to 102.9±2.0 copies/ mL at the end of fol-low-up period. Their mean ages at enrollment, at peak HBV-DNA, at peak ALT, at HBeAg serovonversion, and at final follow-up were 7.0±3.7, 13.4±5.8, 16.3±6.0 , 17.2±5.8, and 23.7±4.1 years, respedtively. The precore mutant appeared more often in the fluctuating- high-viremia group than in the low -viremia group (60.9% vs 22.9%, p=0.004). HBV genotypes had no effect on the viremia profiles. AfterHBeAg seroconverters had decreased viral loads, normal ALT levels, and uneventful coruses after HBeAg seroconversion. A longer follow-up period is necessary to elucidate the significance of HBeAg seroconversion occurring in childhood and young adulthood. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | GASTROENTEROLOGY v.132 n.7 pp.2340-2345 | en |
dc.relation.ispartof | GASTROENTEROLOGY | - |
dc.subject | NATURAL-HISTORY | en |
dc.subject | HEPATOCELLULAR-CARCINOMA | en |
dc.subject | CORE PROMOTER | en |
dc.subject | GENOTYPE | en |
dc.subject | MUTANTS | en |
dc.subject | UPDATE | en |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | Viremia Profiles in Children with Chronic Hepatitis B Virus Infection and Spontaneous E Antigen Seroconversion | en |
dc.type | journal article | en |
dc.relation.pages | 2340-2345 | - |
dc.relation.journalvolume | v.132 | - |
dc.relation.journalissue | n.7 | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en_US | - |
item.cerifentitytype | Publications | - |
顯示於: | 醫學系 |
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