|Title:||Hand, Foot and Mouth Disease Complicated with Central Nervous System Involvement in Taiwan in 1980-1981||Authors:||CHANG, LUAN-YIN
|Keywords:||enterovirus 71;fatality;sequelae;severity||Issue Date:||2007||Journal Volume:||v.106||Journal Issue:||n.2||Start page/Pages:||173-176||Source:||JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION||Abstract:||
Sixteen cases from the 1980-1981 Taiwan outbreak of hand, foot and mouth disease (HFMD) associated with central nervous system involvement were identified: nine had polio- like syndrome, four had encephalitis or encephalomyelitis, one had cerebellitis, and two had aseptic meningitis. They all had fever, five (31%) had documented myoclonic jerk, and 15 (93%) had HFMD. Their mean blood leukocyte count was 12, 490/mu L, and five ( 310/0) had leukocytosis (> 15,000/mu L) ; mean cerebrospinal fluid (CSF) leukocyte count was 156/mu L, CSF protein was 57 mg/dL and CSF glucose was 57 mg/dL. Two patients with HFMD plus encephalitis died within 1 day of hospitalization, and one of them had acute cardiopulmonary failure mimicking myocarditis. Twenty years later, at least one male patient had sequelae of polio-like syndrome and was therefore exempted from military service. Clinical severity was comparable to the 1998 EV71 epidemic.
|Appears in Collections:||醫學系|
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