肝細胞生長因子與BETA型轉化生長因子在人類代償性腎生長與腎肥大所扮演的角色
Date Issued
2000
Date
2000
Author(s)
曹永魁
DOI
892314B002049
Abstract
There was significant nephromegaly in infants with biliary atresia as compared with healthy infants (p < 0.001 by analysis of covariance). Marked nephromcgaly was also noted in all infants with thiminant hepatitis and in 35% of infants with neonatal hepatitis. There was no nephromegaly in infants at 2 months of age with biliary atresia or neonatal hepatitis despite mildly elevated levels of plasma HGF. Irrespective of the duration of
HGF exposure and the healthy renal growth by a certain age, there was a positive correlation between plasma HGF and kidney volume (r = 0.529, p < 0.001), but an inverse correlation between plasma TGF-β1 and nephromegaly (r =
-0.505, p < 0.001) in all diseased infants. These results confirm the presence of large kidneys not only in patients with biliary atresia but also in patients with fulminant hepatitis which suggests the possible pathogenic role of HGF and manifesta as elevated HGF /TGF-β1 ratios in patients with such conditions. Nephromegaly in patients with severe or chronic liver dysfunction may provide a new in vivo model to study the mechanisms of renal growth.
Subjects
hepatoeyte growth factor
transforming growth factor f3
SDGs
Publisher
臺北市：國立臺灣大學醫學院小兒科
Type
report
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