肝細胞生長因子與BETA型轉化生長因子在人類代償性腎生長與腎肥大所扮演的角色

Abstract

我們以超音波檢測嬰充腎臟體積，共計29 位膽道閉鎖17 位新生兒肝炎，10 位猛爆隨肝炎，及32 位健康嬰兒，並檢測其血中HGF 及TGF-β1，膽道閉鎖，猛爆性肝炎，及35%新生兒肝炎嬰兒均有腎肥大現象，這些病人之腎體積與血中HGF呈正相關（r=0.529 ,p < 0001 ）但血中TGF-β1卻呈負相關（r=0 . 505 , p < 0 . 001 ）。 另外對於單一腎臟之代償性腎肥大之病童其血中HGF 與健康孩童無異（數據未示出），因此斷定其腎肥大之機轉應與巉性肝傷害因持續陸HGF 刺激引起之腎肥大之機轉並不相同。

There was significant nephromegaly in infants with biliary atresia as compared with healthy infants (p < 0.001 by analysis of covariance). Marked nephromcgaly was also noted in all infants with thiminant hepatitis and in 35% of infants with neonatal hepatitis. There was no nephromegaly in infants at 2 months of age with biliary atresia or neonatal hepatitis despite mildly elevated levels of plasma HGF. Irrespective of the duration of HGF exposure and the healthy renal growth by a certain age, there was a positive correlation between plasma HGF and kidney volume (r = 0.529, p < 0.001), but an inverse correlation between plasma TGF-β1 and nephromegaly (r = -0.505, p < 0.001) in all diseased infants. These results confirm the presence of large kidneys not only in patients with biliary atresia but also in patients with fulminant hepatitis which suggests the possible pathogenic role of HGF and manifesta as elevated HGF /TGF-β1 ratios in patients with such conditions. Nephromegaly in patients with severe or chronic liver dysfunction may provide a new in vivo model to study the mechanisms of renal growth.