DC 欄位 | 值 | 語言 |
dc.contributor.author | 張美惠 | zh_TW |
dc.creator | 張美惠 | zh_TW |
dc.date | 2002 | zh_TW |
dc.date.accessioned | 2006-07-26T03:07:33Z | - |
dc.date.accessioned | 2018-07-11T17:50:05Z | - |
dc.date.available | 2006-07-26T03:07:33Z | - |
dc.date.available | 2018-07-11T17:50:05Z | - |
dc.date.issued | 2002 | - |
dc.identifier | 902314B002154 | zh_TW |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/22865 | - |
dc.description.abstract | 在B 型肝炎病毒感染之後,不同的病人會有不同的病程及預後。本研究之目的要探討B 型肝炎病毒
之基因型對於兒童慢性B 型肝炎病毒感染臨床病程及e 抗原抗體轉變的影響。
我們長程追蹤250 名慢性B 型肝炎病毒感染之病童之肝功能及B 型肝炎標記,以及B 型肝炎之基因
型。我們將這些兒童分成四組:第一組含68 名兒童,在追蹤過程中一直保持e 抗原陽性的狀況;第二組
156 名兒童,在追蹤過程中由e 抗原陽性轉變成e 抗體陽性;第三組26 名兒童,在進入本研究時已轉變
成e 抗體陽性的狀況。另有25 名兒童為肝細胞癌患者(第四組),均為B 型肝炎慢性感染者。
我們先以基因型特異性聚合鏈(PCR)反應作基因型分類,無法分類者再用限制切割PCR 產物,
判斷其基因型。結果顯示在第一、二、三、四組者屬基因型B 型者分為71%,73%,92%及68%;屬基因型
C 型者,則分別為25%,7%,0%及11%。在長程追蹤中,基因型之轉變發生於10.8%的孩童。
總之,在台灣慢性感染B 型肝炎病毒的兒童中,基因型B 型之B 型肝炎病毒是常見的。基因型C 型
可能會延遲e 抗原抗體轉變。肝癌兒童之B 型肝炎病毒仍以基因型B 型為主。 | zh_TW |
dc.description.abstract | Background/Aim: During the natural history of hepatitis B virus (HBV) infection, clinical course and outcome
differs in different individuals. The aim of this study is to investigate the effect of HBV genotypes on the clinical
course and hepatitis B e antigen/antibody seroconversion during chronic HBV infection. Subjects and Methods:
We longitudinally followed up 250 HBsAg carrier children and performed HBV genotype study in these
children (Group I, 67 children with persistently positive HBeAg; Group II, 148 children who have been
spontaneously seroconverted from HBeAg seropositive to anti-HBe positive during follow-up; Group III, 24
children who have been anti-HBe seropositive when they entered our long term follow-up study). Another 25
children (Group IV) with HBV-related hepatocellular carcinoma (HCC) were also recruited. The genotyping was
performed by polymerase chain reaction (PCR) using type-specific primers. Results: Genotype B was 71%, 73%,
and 92% in Group I, II, and III respectively. Genotype C was 25%, 7%, and 0% in Group I (p=0.01), II, and III
respectively. During long-term follow-up Genotype changing occurred in 10.8% of these 239 study subjects. For
the HCC group (group IV), Genotype B is still predominant (68%) than Genotype C (11%). Conclusion: HBV
Genotype B is the commonest one in children Taiwan. Genotype C might delay HBeAg seroconversion. The role
it played in the pathogenesis of chronic liver damage is worthy of further attention. Genotype changing seemed
not an uncommon event in the natural history of childhood HBV chronic infection. For childhood HCC,
Genotype B is the dominant one. | en |
dc.format | application/pdf | zh_TW |
dc.format.extent | 128672 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language | zh-TW | zh_TW |
dc.language.iso | zh_TW | - |
dc.publisher | 臺北市:國立臺灣大學醫學院小兒科 | zh_TW |
dc.rights | 國立臺灣大學醫學院小兒科 | zh_TW |
dc.subject | B 型肝炎病毒 | zh_TW |
dc.subject | 基因型 | zh_TW |
dc.subject | e 抗原抗體轉變 | zh_TW |
dc.subject | 肝癌 | zh_TW |
dc.subject | 兒童 | zh_TW |
dc.subject | hepatitis B virus | en |
dc.subject | genotype | en |
dc.subject | HBeAg seroconver sion | en |
dc.subject | hepatoma | en |
dc.subject | children | en |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | B型肝炎病毒基因型及表面抗原T細胞抗原決定部位基因變異慢性B型肝炎病毒感染病程的影響(1/3) | zh_TW |
dc.type | report | en |
dc.identifier.uri.fulltext | http://ntur.lib.ntu.edu.tw/bitstream/246246/22865/1/902314B002154.pdf | - |
dc.coverage | 計畫年度:90;起迄日期:2001-08-01/2002-07-31 | zh_TW |
item.fulltext | with fulltext | - |
item.openairetype | report | - |
item.languageiso639-1 | zh_TW | - |
item.openairecristype | http://purl.org/coar/resource_type/c_93fc | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
顯示於: | 醫學系
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