DC 欄位 | 值 | 語言 |
dc.contributor.author | 張美惠 | zh_TW |
dc.creator | 張美惠 | zh_TW |
dc.date | 2003 | zh_TW |
dc.date.accessioned | 2006-07-26T03:07:49Z | - |
dc.date.accessioned | 2018-07-11T17:50:09Z | - |
dc.date.available | 2006-07-26T03:07:49Z | - |
dc.date.available | 2018-07-11T17:50:09Z | - |
dc.date.issued | 2003 | - |
dc.identifier | 912314B002149 | zh_TW |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/22879 | - |
dc.description.abstract | 在慢性B型肝炎病毒感染之自然過程中,其臨床過程及預後因宿主及病毒而
異。若能瞭解影響其臨床過程及預後之因子,有助於決定肝炎防治之策略。本計
畫之目的在 :(一)瞭解在長程追蹤中,帶原兒童B型肝炎病毒表面抗原T細胞
與B細胞抗原決定點基因變化的情形,以及其對臨床病程,B型肝炎病毒標記等
變化之影響。並與B肝最嚴重的合併症,亦即肝細胞癌之兒童做比較。(二)比
較B型肝炎病毒表面抗原T細胞及B細胞抗原決定點基因變異對臨床病程,及B
型肝炎病毒標記等變化之影響在未接受疫苗者與疫苗失敗者的異同。
我們比較長程追蹤的97 名 B型肝炎帶原兒童,及另15 名肝細胞癌兒童之B
型肝炎病毒表面抗原T細胞及B細胞抗原決定點基因在長程追蹤中變異的情
形,以及其對臨床病程,及B型肝炎病毒標記等變化的影響。另比較未接受疫苗
者與在嬰兒期接受B型肝炎預防注射者,其B型肝炎病毒表面抗原T細胞抗原
決定點基因變異之情形。結果發現肝細胞癌兒童之B型肝炎病毒表面抗原T細
胞抗原決定點基因之變異率比慢性B型肝炎病毒感染但無肝癌之兒童較高
(46.7% v.s. 6.2%, p=0.0013).此現象並未發生於B型肝炎病毒表面抗原B細胞抗原
決定點基因。B型肝炎病毒表面抗原B細胞抗原決定點基因之突變則較常發生於
接受過B 肝預防注射的兒童。
總之, 肝細胞癌兒童之B型肝炎病毒表面抗原T細胞抗原決定點基因比慢性
B型肝炎病毒感染但無肝癌之兒童有較高的變異率. 此間差異比成人之肝癌與非
肝癌帶原者相比更加顯著。兒童肝癌之早期癌形成與此B型肝炎病毒表面抗原
T細胞抗原決定點基因變異可能有關, 然而是因是果仍待進一步研究。 | zh_TW |
dc.description.abstract | The aims of this study are (1) to investigate the role of mutation at the HLAclass
I restricted T cell epitope and B cell epitope of hepatitis B surface antigen
(HBsAg) gene in the natural course of children with chronic hepatitis B virus ( HBV)
infection with and
without hepatocellular carcinoma (HCC), and (2) to compare the mutation rates at the
T cell epitope and the B cell epitope in children with chronic HBV infection and HCC
with and without hepatitis B immunoprophylaxis in infancy.
We have longitudinally followed 97 HBsAg carrier children, 53 did and 44 did
not receive hepatitis B immunoprophylaxis during infancy. T cell epitope amino acids
28-51 at the HBV surface gene has been studied in those 97 children and another 15
children with HBV related HCC. Children with HCC showed a significantly higher
rate of T cell epitope mutation at amino acid residue 40-49 than children without HCC
(46.7% v.s. 6.2%, p=0.0013). No difference in the rate of B cell epitope mutation was
found between children with and without HCC (p > 0.1). A trend of higher mutation
rate in the B-cell epitope was observed in children who received HBV vaccination
than in children without vaccination (22.4% v.s. 9.3%, p=0.063). No difference in the
mutation rate at T cell epitope domain of the HBsAg gene was found between those
who were unvaccinated and those who were vaccinated during infancy (p > 0.1 ).
In conclusion, Mutations at the T cell epitope amino acid residue 40-49 were
much more frequently found in childhood HCC than HBV carriers children. Its
relationship with early hepatocarcinogenesis requires further investigation. | en |
dc.format | application/pdf | zh_TW |
dc.format.extent | 138681 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language | zh-TW | zh_TW |
dc.language.iso | zh_TW | - |
dc.publisher | 臺北市:國立臺灣大學醫學院小兒科 | zh_TW |
dc.rights | 國立臺灣大學醫學院小兒科 | zh_TW |
dc.subject | 慢性B型肝炎病毒感染 | zh_TW |
dc.subject | 肝細胞癌兒童 | zh_TW |
dc.subject | B型肝炎病毒表面抗原T細胞抗原決定點基因 | zh_TW |
dc.subject | B型肝炎病毒表面抗原B細胞抗原決定點基因 | zh_TW |
dc.subject | chronic hepatitis B virus infection | en |
dc.subject | hepatocellular carcinoma in children | en |
dc.subject | T cell epitope on hepatitis B surface gene | en |
dc.subject | B cell epitope on hepatitis B
surface gene | en |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | B型肝炎病毒基因型及表面抗原T細胞抗原決定部位基因變異慢性B型肝炎病毒感染病程的影響(2/3) | zh_TW |
dc.type | report | en |
dc.identifier.uri.fulltext | http://ntur.lib.ntu.edu.tw/bitstream/246246/22879/1/912314B002149.pdf | - |
dc.coverage | 計畫年度:91;起迄日期:2002-08-01/2003-07-31 | zh_TW |
item.openairecristype | http://purl.org/coar/resource_type/c_93fc | - |
item.openairetype | report | - |
item.languageiso639-1 | zh_TW | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.fulltext | with fulltext | - |
顯示於: | 醫學系
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