β1型轉化生長因子於腎肥大過程中肝細胞生長因子失調之角色

Abstract

我們將25 天大之大白鼠右腎切除研究其左腎於術後6 小時、12 小時、24 小時、48 小時、72 小時及7 天之腎臟生長及肝細胞生長因子(HGF)，β1 型轉化 生長因子(TGF-β1)、C-met 蛋白及TGF-β1 mRNA之變化情形。結果發現腎中HGF/ TGF-β1 比值於術後12 小時實驗組有意義高於控制組，而TGF-β1 mRNA 則於 12-24 小時達到最低，C-met 蛋白則在6~24 小時明顯增加，而顯著的腎肥大(腎 臟重量增加)則發生在術後7 天之實驗組。

Kidney growth and growth factors change were observed after unilateral nephrectomy in the 25-day-old rats. Renal HGF/TGF-β1 ratio was found significantly higher at 12 hours after nephrectomy. C-met receptor protein was remarkably increased at the first 24 hours associated with low renal TGF-β1 and TGF-β1 mRNA at least at the 12~24 hours after nephrectomy. Kidney weight was increased at 7 days after nephrectomy, but not in the first 72 hours.