https://scholars.lib.ntu.edu.tw/handle/123456789/194551
標題: | Mapping of Psoriasis to 17q Terminus | 作者: | HWU, WUH-LIANG FANN, CATHY SHENG-JIUAN TSAI, TSEN-FANG CHIEN, YIN-HSIU CHIANG, SHU-CHUAN WU, JER-YUARN CHEN, YUAN-TSONG |
關鍵字: | psoriasis;PSORS2;genome-wide scan;17q terminus;tubulin- specific chaperone d gene | 公開日期: | 2005 | 卷: | v.42 | 期: | n.2 | 起(迄)頁: | 152-158 | 來源出版物: | JOURNAL OF MEDICAL GENETICS | 摘要: | Psoriasis is a chronic, inflammatory, hyperproliferative disease of the skin, scalp, nails, and joints, with a prevalence of up to 2% in Caucasians1,2 but well under 1% in the Mongoloid races of the Far East.3 The disease varies in severity. Some patients display mild disease with isolated scaling erythematous plaques on the elbows or knees, whereas for others most of their cutaneous surface can be affected. At the cellular level, psoriasis is characterised by markedly increased epidermal proliferation and incomplete differentiation, elongation, dilation, and leakiness of the superficial plexus of dermal capillaries, and by a mixed inflammatory and immune cell infiltrate of the epidermis and papillary dermis.1,2 Dermal infiltrates comprised of T cells and macrophages typically appear in early lesions before epidermal changes.4 The therapeutic effect of immunosuppressive agents suggests psoriasis has a primary immune pathogenic basis.5 inflammatory and immune cell infiltrate of the epidermis and papillary dermis.1,2 Dermal infiltrates comprised of T |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/88744 |
顯示於: | 醫學系 |
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