https://scholars.lib.ntu.edu.tw/handle/123456789/194553
標題: | Responses of Igm for Enterovirus 71 Infection | 作者: | CHANG, LUAN-YIN | 公開日期: | 2002 | 卷: | VIROLOGY | 期: | n.4 | 起(迄)頁: | 574-580 | 來源出版物: | JOURNAL OF MEDICAL | 摘要: | A rapid serological assay was developed for detection of specific IgM to enterovirus 71, a human picornavirus that is usually associated with severe central nervous system complications. The sensitivity and specificity of this "in- house" mu-capture enzyme linked-immunosorbent assay was assessed by testing 213 serum samples. With the conventional virus culture as a standard method, the sensitivity and specificity were 91.5 and 93.1%, respectively, for this newly developed immunoassay. This method allows for detection of the IgM responses from the patients either infected by genotype B or genotype C of enterovirus 71. IgM can be detected as early as the second day from the onset of disease. IgM responses exhibit 100% positive rate from enterovirus 71-infected patients with complications, including encephalitis, meningitis, polio-like syndrome, pulmonary edema, and fatal cases. These findings suggest that detection of specific IgM by the use of enzyme linked- immunosorbent assay is a rapid and valuable way for the diagnosis of enterovirus 71 infection . |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/88746 |
顯示於: | 醫學系 |
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