心臟衰竭之研究與藥物探索─心電生理特性，抗心律不整效力及不整脈誘發性之測定，包括CARVEDILOL及THALIDOPARHINE等新衍發物(2/3)
Date Issued
2000
Date
2000
Author(s)
吳美環
DOI
892320B002019M48
Abstract
Background. We have identified the
compound, thalidoporphine, to possess an
antiarrhythmia potential and a low negative
inotropy.
Methods. The direct modification by various
interventions on cardiac conduction system
was performed by intracardiac recording and
stimulation in isolated, Langendorff perfused
hearts. The changes were measured in the
hearts isolated from normal and
cardiomyopathic hamster.
Results. As compared to the normal hamster,
the failing heart isolated from the
cardiomyopathic hamster showed significantly
prolongation of the conduction through the
AV node as well as the refractoriness of the
AV node (AH interval was 44±3 in normal
and 56±4 ms in the failing hearts. The
Wenckebach cycle length was 149±9 ms in
normal and 195±13 ms in the failing hearts).
Pretreatment by thalidophorphine (4.5 mg/day)
improved the conduction. The AH interval
was shortened to 48±2 ms and the
Wenckebach cycle length was shortened to
176±6 ms. There was no significant
differences in the conduction and refractory
period of the atrial and ventricular tissue
between the normal and heart failure hamster.
However, pretreatment by thlidophorine
would increase the atrial refractory period.
(the atrial effective refractory period was
45±3 in normal, 41±4 in failing hearts and
54±7 ms in the thlaidophorine group). No
arrhythmia could be induced by programmed
pacing in any of the 3 groups. However,
thlidoporphine still could prolong the
conduction through the AV node, the
refractory period of the atrial and ventricular
tissue dose-dependently in both normal and
failing hearts of cardiomyopathic hamsters.
Conclusions. Failing heart of the
cardiomyopathic hamster was characterized
by a prolongation of conduction and refractory
period of the AV node, which could be
improved by pretreatment by thlidoporphine.
Nonetheless, thalidoporphine could prolong
the AV conduction and refractory period of
the atrial and ventricular period of the
cardiomyopathic hamster and normal hamster.
Publisher
臺北市：國立臺灣大學醫學院小兒科
Type
report
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