DC 欄位 | 值 | 語言 |
dc.contributor.author | 吳美環 | zh_TW |
dc.creator | 吳美環 | zh_TW |
dc.date | 2000 | zh_TW |
dc.date.accessioned | 2006-08-31T07:14:42Z | - |
dc.date.accessioned | 2018-07-11T17:51:33Z | - |
dc.date.available | 2006-08-31T07:14:42Z | - |
dc.date.available | 2018-07-11T17:51:33Z | - |
dc.date.issued | 2000 | - |
dc.identifier | 892320B002019M48 | zh_TW |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/29834 | - |
dc.description.abstract | 1. 本實驗室工作群長期致力於由天然植
物萃取有效之化合物。經評估後,目
前有兩大類化合物, 一為
thalidiporphine , 一為
liriodenine,兩者皆具有適宜之心肌
收縮促進效果及抗心律不整效力。
2. 因此本群體計劃之目的在(1)將此兩大
類化合物予以改變部份結構,使具有
部份α與β拮抗作用(2)且能維持充份
之心臟收縮促進效果及抗心律不整效
力。
3. 本子計劃之主要工作在執行(1)第一
年:先界定carvedilol是否有直接抗
心律不整效力,或對心臟電生理特性
有直接影響,若有,其機轉為何?(2)
其次, 第二年: 將予界定
thalidoporplinie各類衍生物之抗心
律不整之效力及對心臟傳導系統之影
響(3)第三年:將予界定liriodenine
各類衍生物之抗心律不整之效力及對
心臟傳導系統之影響。
4. 方法:(1)心臟電生理特性之評估:以
Langendorff灌流之離體心臟作評估,
以自製特別之電極導線放入心房、心
室及希氏束處,記錄並刺激,以得到
各項組織之電生理特性資料。
實驗:(2) 動物:一般正常hamster及心
衰竭品種hamster。
5. 第二年計劃結果顯示:結果顯示心衰
竭hamster的心臟傳導系統有顯著房室
結之傳導延長現象,其AH間距由44±3
延長到56±4ms,而wenckrbach週期由
149±9延長到195±13ms。而若在實驗
前每天投予thalidoporphine 4.5mg/day
則可有效縮短這些延長現象。此外,
thalidoporphine pretreatment能有效延長
心房的refroctory period。然而不論是
正常或心衰竭hamster的離體灌流心
臟,thalidoporphine皆能有效依劑量成
正比的延常房室結的傳導與
refractoriness。6. 推論:thalidoporphine能改善心衰竭心
臟電氣傳導性質,然而這些影響與
thalidoporphine的直接心臟效果並不盡
然相同,自主神經系之調節或抗氧化
的作用是必須考慮的機轉。 | zh_TW |
dc.description.abstract | Background. We have identified the
compound, thalidoporphine, to possess an
antiarrhythmia potential and a low negative
inotropy.
Methods. The direct modification by various
interventions on cardiac conduction system
was performed by intracardiac recording and
stimulation in isolated, Langendorff perfused
hearts. The changes were measured in the
hearts isolated from normal and
cardiomyopathic hamster.
Results. As compared to the normal hamster,
the failing heart isolated from the
cardiomyopathic hamster showed significantly
prolongation of the conduction through the
AV node as well as the refractoriness of the
AV node (AH interval was 44±3 in normal
and 56±4 ms in the failing hearts. The
Wenckebach cycle length was 149±9 ms in
normal and 195±13 ms in the failing hearts).
Pretreatment by thalidophorphine (4.5 mg/day)
improved the conduction. The AH interval
was shortened to 48±2 ms and the
Wenckebach cycle length was shortened to
176±6 ms. There was no significant
differences in the conduction and refractory
period of the atrial and ventricular tissue
between the normal and heart failure hamster.
However, pretreatment by thlidophorine
would increase the atrial refractory period.
(the atrial effective refractory period was
45±3 in normal, 41±4 in failing hearts and
54±7 ms in the thlaidophorine group). No
arrhythmia could be induced by programmed
pacing in any of the 3 groups. However,
thlidoporphine still could prolong the
conduction through the AV node, the
refractory period of the atrial and ventricular
tissue dose-dependently in both normal and
failing hearts of cardiomyopathic hamsters.
Conclusions. Failing heart of the
cardiomyopathic hamster was characterized
by a prolongation of conduction and refractory
period of the AV node, which could be
improved by pretreatment by thlidoporphine.
Nonetheless, thalidoporphine could prolong
the AV conduction and refractory period of
the atrial and ventricular period of the
cardiomyopathic hamster and normal hamster. | en |
dc.format | application/pdf | zh_TW |
dc.format.extent | 40831 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language | zh-TW | zh_TW |
dc.language.iso | zh_TW | - |
dc.publisher | 臺北市:國立臺灣大學醫學院小兒科 | zh_TW |
dc.rights | 國立臺灣大學醫學院小兒科 | zh_TW |
dc.title | 心臟衰竭之研究與藥物探索─心電生理特性,抗心律不整效力及不整脈誘發性之測定,包括CARVEDILOL及THALIDOPARHINE等新衍發物(2/3) | zh_TW |
dc.type | report | en |
dc.identifier.uri.fulltext | http://ntur.lib.ntu.edu.tw/bitstream/246246/29834/1/892320B002019M48.pdf | - |
dc.coverage | 計畫年度:89
第一期;起迄日期:1999-08-01/2000-07-31 | zh_TW |
item.openairecristype | http://purl.org/coar/resource_type/c_93fc | - |
item.openairetype | report | - |
item.languageiso639-1 | zh_TW | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.fulltext | with fulltext | - |
顯示於: | 醫學系
|