https://scholars.lib.ntu.edu.tw/handle/123456789/194710
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 小兒科 | en |
dc.contributor.author | CHIANG, BOR-LUEN | en |
dc.creator | 江伯倫 | zh-tw |
dc.creator | CHIANG, BOR-LUEN | en |
dc.date | 1998 | en |
dc.date.accessioned | 2008-12-10T08:39:32Z | - |
dc.date.accessioned | 2018-07-11T17:52:00Z | - |
dc.date.available | 2008-12-10T08:39:32Z | - |
dc.date.available | 2018-07-11T17:52:00Z | - |
dc.date.issued | 1998 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/90395 | - |
dc.description.abstract | Objective:The aim of this study is to establish an animal model to investigate the role of individual subsets of immune cells in the pathogenesis of systemic lupus erythematosus.Methods:Spleen cells isolated from both young and old autoimmune NZB/W F1 mice were injected into the peritoneal cavity of severe combined immunodeficient (SCID) mice. Sera anti-DNA antibody levels and proteinuria of these SCID mice were followed regularly. In addition, histological changes of the kidneys were also examined. Results:The data suggest that anti-ss, dsDNA antibody can be detected in the sera of SCID mice 21 days after reconstitution with the spleen cells of either young or old NZB/W Fl mice, with titers of antibody increasing over time. In addition, proteinuria was also noted in most of these mice 3 months after reconstitution. Histopathological examination of the kidney also revealed the typical changes of glomerulonephritis. Immunofluorescence staining of kidney sections also demonstrated immune complex deposition. Conclusion:Once validated, this animal model could be used in future studies to investigate the role of individual subsets of cells in the pathogenic mechanisms of SLE. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | CLINICAL AND EXPERIMENTAL RHEUMATOLOGY v.16 n.1 pp.33-37 | en |
dc.relation.ispartof | CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | - |
dc.title | Reconstitution of Severe Combined Immunodeficient Mice with Spleen Cells from Autoimmune Nzbxnzw F1 Mice | en |
dc.type | journal article | en |
dc.relation.pages | 33-37 | - |
dc.relation.journalvolume | v.16 | - |
dc.relation.journalissue | n.1 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
顯示於: | 醫學系 |
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