Analysis of Total Ige and Allergen-Specific Ige Antibody Levels of Allergic Children in Taiwan

隨時代技術進步，分析過敏原的方式也漸趨多樣。本研究用Pharmacia-CAP系統檢測 造成過敏性疾病如支氣管氣喘，過敏性鼻炎，異位性皮膚炎及蕁麻疹的過敏原。392 位小朋友於84年3月至84年8月到台大醫院小兒部就診，被囊括入本研究中。結果如下 ：(1)392位小朋友包括82位支氣管氣喘，70位過敏性鼻炎，22位異位性皮膚炎，156 位支氣管氣喘加過敏鼻炎，8位支氣管氣喘加異位性膚炎，12位過敏性鼻炎加異位性 皮膚炎，42位三合一疾病(支氣管氣喘加過敏性鼻炎加異位性皮膚炎同時存在)。(2) 麈蟎是台灣最重要的過敏原(3)三合一疾病(支氣管氣喘加過敏性鼻炎加異位性 皮膚炎同時存在)的total IgE最高，而單一過敏性疾病過敏性鼻炎的 total IgE最低 。麈蟎專一IgE抗體中三合一疾病(支氣管氣喘加過敏性鼻炎加異位性膚炎同時 存在)的麈蟎專一IgE抗體最高，而單一疾病過敏性鼻炎的麈蟎專一IgE 最低。(4)異位性膚炎／蕁麻疹的過敏病人中蛋白及牛奶過敏原僅只於皮膚過敏中較 有意義。此外，過敏性疾病愈複雜嚴重IgE愈高。 With advances in technology, several in vitro screening tests such as MAST and CAP system have been used for analyzing the allergens involved in allergic diseases such as bronchial asthma (BA), allergic rhinitis (AR), atopic dermatitis (AD) and urticaria. In this study, CAP system (Pharmacia, Sweden) was used to screen the prevalence of allergens responsible for these atopic diseases. A total of 392 children were enrolled in this study retrospectively, all these atopic children visited the allergy clinic of the Department of Pediatrics, National Taiwan University Hospital during the period March 1995 and August 1995. Our results showed: (1) Among these 392 allergic children, included 82 BA, 70 AR, 22 AD, 156 BA+AR, 8 BA+AD, 12 AR+AD, and 42 AD+AR+AD; (2) House dust mites ( Dermatophagoides pteronyssinus: D. p and Dermatophagoidesfarinae: D. f) are the most common allergens triggering atopic disease in the Taiwan area. (3) Total IgE level is the highest in three combined allergic disease (BA +AR+AD)[2179.9±504.2KU/L] and lowest in single disease (AR) [503.1±84.8 KU/L]. Mite-specific IgE (D . p+D. f-specific IgE) concentration is also the highest in three combined disease (BA+AR+AD) [499.1±86.OKU/L] and lowest in AR [159.5±47.5 KU/L], (4) elevated specific IgE antibody to egg white and milk were found in 68 .4% and 47.4% of patients with AD and/or urticaria. In conclusion, these data suggest that house dust mites, are the most important allergens in respiratory allergy as well as in atopic dermatitis, while food allergens play relatively important roles only in skin allergy. Furthermore, the highest IgE level was noted in children with combined allergic diseases.