|Title:||Antibodies to E2 Protein of Hepatitis G Virus in Children: Different Responses According to Age at Infection||Authors:||CHEN, HUEY-LING
|Issue Date:||1998||Journal Volume:||v.133||Journal Issue:||n.3||Start page/Pages:||382-385||Source:||THE JOURNAL OF PEDIATRICS||Abstract:||
Objectives : To study viral persistence and antibody responses after hepatitis G virus (HGV) infection in children of various ages. Study design: We performed an enzyme immunoassay for antibodies to E2 protein ( anti-E2) of HGV and reverse-transcription polymerase chain reaction assay for HGV RNA on serum samples. Results: Of 28 infants born to HGV RNA- positive mothers, 17 were found to be positive for HGV RNA. None were positive for anti-E2. All 17 infected in-fants continued to have viremia except 1 who converted to HGV RNA-negative status at 24 months. Six infants had mild elevations of alanine aminotransferase levels (5 HGV- positive and 1 HGV-negative ). An additional 14 HGV-infected children ( aged 6 months to 14 years) with posttransfusion HGV infection were positive for anti-E2 1 year later. Conclusions: Mother-to-infant transmission of HGV resulted in a high viral per-sistence rate and lack of immune responses to HGV. In contrast, anti-E2 appeared in children who recovered form posttransfusion HGV infection. Mode of transmission and age at infection may be important factors in determining persistent HGV infection and deffective immune response to HGV.
|Appears in Collections:||醫學系|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.