https://scholars.lib.ntu.edu.tw/handle/123456789/194747
標題: | Eactors Affecting the Severityof Neonatal Jaundice of Unknown Etiology: The Role of Enterohepatic Circulation 影響生理性黃疸之因素:特別著重膽紅素腸肝循環之解色 |
作者: | 鄒國英 YAU KOU-INN, TSOU |
關鍵字: | 新生兒黃疸;母乳哺育;腸肝循環;B-尿甘酸化物酵素;NEONATAL JAUNDICE;BREAST FEEDING;ENTEROHEPATIC CIRCULATION;B-GLUCURONIDASE | 公開日期: | 1992 | 期: | n.1 | 起(迄)頁: | 20-28 | 來源出版物: | 中華民國小兒科醫學會雜誌,v.33 | 摘要: | Jaundice is the most common condition of otherwise healthy, full-term newborns during the first week of life, and Chinese newborns are known to have a higher incidence and severity of neonatal jaundice than Caucasian newborns. This prospective study was designed to examine factors affecting the severity of neonatal jaundice of unknown etiology in the first week of life with special emphasis on the role of enterohepatic circulation. One hundred and thirty-six healthy, full-term newborns were enrolled in this study. Serum bilirubin levels were monitored daily in the morning for the first five days after delivery. Cord blood, postpartal maternal blood , breast milk and infants' stools were analyzed for beta-glucuronidase activity. Infants with serum peak bilirubin level less than or equal to 7 mg/dl had older gestational age, less maximal weight loss and the bilirubin levels peaked at an earlier age than those infants with peak serum bilirubin level more than 7 mg/dl. They also had lower fecal beta- glucuronidase activity in the stool collected at a mean age of 4.5(+/- 0.6 ) days. Among the 136 study cases, 92 infants received some maternal breast milk. There was considerable amount of beta- glucuronidase activity in the human breast milk. Yet its presence did not affect the fecal enzyme activity. Mixed breast feeding also did not influence the serum bilirubin level in the first four days of life. However, infants fed dominantly with breast milk had a higher incidence of serum bilirubin level more than 10 mg/dl at five days old than infants fed solely by infant formula.(ABSTRACT TRUNCATED AT 250 WORDS) |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/92473 |
顯示於: | 醫學系 |
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