|Title:||Transplantation for Adrenoleukodystrophy with Hla-a and B Nonidentical Paternal Marrow: Report of One Case||Authors:||LIN, KAI-HSIN
|Issue Date:||1998||Journal Issue:||n.4||Start page/Pages:||260-3||Source:||中華民國小兒科醫學會雜誌,v.39||Abstract:||
We report the result of allogeneic bone marrow transplantation (BMT) in a 14-year-old boy who was neurologically severely involved with the childhood form of adrenoleukodystrophy (ALD) and received marrow from his HLA- A and B nonidentical, MLC-nonreactive paternal donor without T-cell depletion processing. Bone marrow transplantation corrected the excess content of very long chain fatty acid in plasma but did not arrest the deterioration of the neurological status during 3.5-year post-transplant follow- up period. Since partially matched or unrelated donors have been applied to clinical BMT successfully with current new techniques, ALD patients will have a better prognosis when they are transplanted in status of mild and early involvement. Our first experience may be helpful in more trials of BMT for genetic leukodystrophy in Taiwan.
|Appears in Collections:||醫學系|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.