https://scholars.lib.ntu.edu.tw/handle/123456789/194803
Title: | Transplantation for Adrenoleukodystrophy with Hla-a and B Nonidentical Paternal Marrow: Report of One Case | Authors: | LIN, KAI-HSIN WANG, PEN-JUNG |
Issue Date: | 1998 | Journal Issue: | n.4 | Start page/Pages: | 260-3 | Source: | 中華民國小兒科醫學會雜誌,v.39 | Abstract: | We report the result of allogeneic bone marrow transplantation (BMT) in a 14-year-old boy who was neurologically severely involved with the childhood form of adrenoleukodystrophy (ALD) and received marrow from his HLA- A and B nonidentical, MLC-nonreactive paternal donor without T-cell depletion processing. Bone marrow transplantation corrected the excess content of very long chain fatty acid in plasma but did not arrest the deterioration of the neurological status during 3.5-year post-transplant follow- up period. Since partially matched or unrelated donors have been applied to clinical BMT successfully with current new techniques, ALD patients will have a better prognosis when they are transplanted in status of mild and early involvement. Our first experience may be helpful in more trials of BMT for genetic leukodystrophy in Taiwan. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/92538 |
Appears in Collections: | 醫學系 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.