|Title:||Epstein - Barr Virus - Associated Peripheral T-Cell Lymphome of Actirated Cd8 Phenotype||Authors:||SU, IH-JEN
|Keywords:||EB病毒;末稍T淋巴瘤;血液疾病;EPSTEIN-BARR VIRUS;PERIPHERAL T-CELL LYMPHOMA;HEMATOLOGIR DISEASES||Issue Date:||1990||Journal Volume:||v.66||Journal Issue:||n.12||Start page/Pages:||2557-2562||Source:||CANCER||Abstract:||
Two childhood cases are reported of peripheral T-cell lymphoma; the neoplastic cells expressed activated CD8 (T8) phenotype and contained Epstein-Barr viral (EBV) DNA. Both patients had an aggressive and rapid clinical course despite chemotherapy. Elevated titers of antibodies to EBV -viral capsid antigen (>640) and early antigen (>10) were found in both patients. Histology revealed pleomorphic immunoblastic lymphoma with extensive necrosis in one case and an angioimmunoblastic lymphadenopathy- like pattern containing Reed-Sternberg-like giant cells in the other. Southern blot hybridization studies showed clonal rearrangement of the T- cell-receptor beta gene in both cases, and a cytogenetic study on one case revealed clonal structural abnormality involving chromosomes 1, 6, 7, 10, and 19. Analysis of the tumor DNA showed a high copy numberof EBV genome per cell compared with that of Raji and Marmoset B 95.8 lines; the study for human T-cell leukemia virus type I was negative. The EBV genome was found by in situ hybridization in the tumor nuclei in both cases. In addition to Burkitt's lymphoma, T-cell lymphoma of the helper phenotype, and Hodgkin's disease, EBV can contribute to the development of CD8- positive aggressive T-cell lymphoma.#A1390025
|Appears in Collections:||醫學系|
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