https://scholars.lib.ntu.edu.tw/handle/123456789/194838
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 小兒科 | en |
dc.contributor.author | CHANG, MEI-HWEI | en |
dc.contributor.author | HSU, HONG-YUAN | en |
dc.contributor.author | CHEN, HUEY-LING | en |
dc.contributor.author | JENG, YUNG-MING | en |
dc.contributor.author | NI, YEN-HSUAN | en |
dc.contributor.author | TSUEI, DAW-JEN | en |
dc.contributor.author | HUANG, HSIANG-PO | en |
dc.creator | 張美惠;許宏遠;陳慧玲;鄭永銘;倪衍玄;崔道貞;黃祥博 | zh-tw |
dc.creator | CHANG, MEI-HWEI;HSU, HONG-YUAN;CHEN, HUEY-LING;JENG, YUNG-MING;NI, YEN-HSUAN;TSUEI, DAW-JEN;HUANG, HSIANG-PO | en |
dc.date | 2005 | en |
dc.date.accessioned | 2008-12-22T03:16:43Z | - |
dc.date.accessioned | 2018-07-11T17:53:21Z | - |
dc.date.available | 2008-12-22T03:16:43Z | - |
dc.date.available | 2018-07-11T17:53:21Z | - |
dc.date.issued | 2005 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/92594 | - |
dc.description.abstract | Background and Aim: Integration of hepatitis B virus-DNA ( HBV-DNA) into the host genome, a phenomenon found frequently in hepatocellular carcinomas (HCC) and causally linked to oncogenesis, has not been well characterized in children. The aim of the present study was to determine the prevalence of HBV integration more accurately and to decide whether the integration rate varies at different stages of chronic HBV infection in children. Methods: Of 13 children with chronic hepatitis, 14 liver biopsy tissues were analyzed. One liver tissue with pure liver cirrhosis, nine non-tumor, and nine tumor liver tissues from children with HCC were analyzed by a very sensitive method, inverse polymerase chain reaction ( IPCR). Results: Thirteen genuine viral-host junctional sequences from 23 patients were successfully isolated and proved that IPCR is a useful method in this context. The results also indicated that the detection rate of HBV-DNA integration increased in parallel with the progress of liver histology towards the neoplastic transformation, with 0% in the liver of chronic hepatitis, 22.2% in non-tumor livers of HCC patients, and 66.7% in tumor liver tissues of HCC patients. Conclusion: The present results indicate that integration of HBV-DNA into the host genome was rarely confirmed at the early stage of chronic hepatitis in children until the stage of HCC formation. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY v.20 n.8 pp.1206-1214 | en |
dc.relation.ispartof | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | - |
dc.subject | chronic hepatitis | en |
dc.subject | hepatitis B virus | en |
dc.subject | hepatocellular carcinoma | en |
dc.subject | integration | en |
dc.subject | inverse polymerase chain reaction | en |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | Differential Integration Rates of Hepatitis B Virus DNA in the Liver of Children with Chronic Hepatitis B Virus Infection and Hepatocellular Carcinoma | en |
dc.type | journal article | en |
dc.relation.pages | 1206-1214 | - |
dc.relation.journalvolume | v.20 | - |
dc.relation.journalissue | n.8 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
顯示於: | 醫學系 |
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