https://scholars.lib.ntu.edu.tw/handle/123456789/194864
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 小兒科 | en |
dc.contributor.author | SUEN, JAU-LING | en |
dc.contributor.author | CHIANG, BOR-LUEN | en |
dc.creator | 孫昭玲;江伯倫 | zh-tw |
dc.creator | SUEN, JAU-LING;CHIANG, BOR-LUEN | en |
dc.date | 2006 | en |
dc.date.accessioned | 2008-12-22T03:20:34Z | - |
dc.date.accessioned | 2018-07-11T17:54:18Z | - |
dc.date.available | 2008-12-22T03:20:34Z | - |
dc.date.available | 2018-07-11T17:54:18Z | - |
dc.date.issued | 2006 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/92620 | - |
dc.description.abstract | Systemic lupus erythematosus (SLE) is a chronic, systemic autoimmune disease characterized by the loss of tolerance to self-antigen. Because it is currently not known if regulatory T (T-reg) cells are involved in the pathogenesis, we determined the frequency of CD4(+)CD25(+) T cells and assayed the related gene expression levels in CD4(+)CD25(+) T cells isolated from both lupus mice (NZB/NZW F-1) and normal control mice (DBA2/ NZW F-1). The results showed that the frequency of CD4(+)CD25(+) T cells in lupus mice was lower than that of normal mice. Except for the high expression level of interleukin (IL)-10 mRNA, CD4(+)CD25(+) T cells from lupus mice expressed normal forkhead box P3 ( Foxp3) and transforming growth factor (TGF)-beta mRNA, and exerted suppressive functions. Furthermore, we depleted CD25 (+) T-reg cells of non-autoimmune mice with anti-CD25 antibody and broke their tolerance with apoptotic cell- pulsed dendritic cells for the follow-up of autoantibody levels. The mice in the CD25(+) cell-depleted group had higher titres of anti-double-strand/single -strand DNA antibodies than those of the isotype control antibody- treated group. These findings indicated that CD4(+)CD25(+) T cells might be involved in the regulatory mechanism of autoantibody production. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | CLINICAL AND EXPERIMENTAL IMMUNOLOGY v.145 n.3 pp.513-519 | en |
dc.relation.ispartof | CLINICAL AND EXPERIMENTAL IMMUNOLOGY | - |
dc.subject | autoantibodies | en |
dc.subject | lupus, systemic lupus erythematosus | en |
dc.subject | regulatory T cel | en |
dc.title | The Role of Cd4(+)Cd25(+) T Cells in Autoantibody Production in Murine Lupus | en |
dc.type | journal article | en |
dc.relation.pages | 513-519 | - |
dc.relation.journalvolume | v.145 | - |
dc.relation.journalissue | n.3 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
顯示於: | 醫學系 |
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