|Title:||Morin Promotes the Production of Th2 Cytokine by Modulating Bone Marrow- Derived Dendritic Cells||Authors:||SUEN, JAU-LING
LEE, CHAO PEI-DAWN
|Keywords:||morin;dendritic cells;helper T type 1 (Th 1);helper T type 2 (Th2)||Issue Date:||2006||Journal Volume:||v.34||Journal Issue:||n.4||Start page/Pages:||667-684||Source:||AMERICAN JOURNAL OF CHINESE MEDICINE||Abstract:||
Our previous studies had reported that morin decreased the interleukin-12 (IL-12) and tumor necrosis factor-alpha (TNF- alpha) production in lipopolysaccharide (LPS)-activated macrophages, suggesting that morin may promote helper T type 2 (Th2) response in vivo. Dendritic cells (DCs) are the most potent antigen presenting cells and known to play a major role in the differentiation of helper T type 1 (Th1) and Th2 responses. This study aimed to reveal whether morin is able to control the Th differentiation through modulating the maturation and functions of DCs. Bone marrow-derived dendritic cells (BM-DCs) were incubated with various concentrations of morin and their characteristics were studied. The results indicated that morin significantly affects the phenotype and cytokine expression of BM-DCs. Morin reduced the production of IL-12 and TNF-alpha in BM- DCs, in response to LPS stimulation. In addition, the proliferative response of stimulated alloreactive T cells was significantly decreased by morin in BM-DCs. Furthermore, allogeneic T cells secreted higher IL-4 and lower IFN-gamma in response to morin in BM- DCs. In conclusion, these results suggested that morin favors Th2 cell differentiation through modulating the maturation and function of BM-DCs.
|Appears in Collections:||醫學系|
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