https://scholars.lib.ntu.edu.tw/handle/123456789/194865
標題: | Morin Promotes the Production of Th2 Cytokine by Modulating Bone Marrow- Derived Dendritic Cells | 作者: | SUEN, JAU-LING CHIANG, BOR-LUEN LEE, CHAO PEI-DAWN FANG, SHIH-HUA |
關鍵字: | morin;dendritic cells;helper T type 1 (Th 1);helper T type 2 (Th2) | 公開日期: | 2006 | 卷: | v.34 | 期: | n.4 | 起(迄)頁: | 667-684 | 來源出版物: | AMERICAN JOURNAL OF CHINESE MEDICINE | 摘要: | Our previous studies had reported that morin decreased the interleukin-12 (IL-12) and tumor necrosis factor-alpha (TNF- alpha) production in lipopolysaccharide (LPS)-activated macrophages, suggesting that morin may promote helper T type 2 (Th2) response in vivo. Dendritic cells (DCs) are the most potent antigen presenting cells and known to play a major role in the differentiation of helper T type 1 (Th1) and Th2 responses. This study aimed to reveal whether morin is able to control the Th differentiation through modulating the maturation and functions of DCs. Bone marrow-derived dendritic cells (BM-DCs) were incubated with various concentrations of morin and their characteristics were studied. The results indicated that morin significantly affects the phenotype and cytokine expression of BM-DCs. Morin reduced the production of IL-12 and TNF-alpha in BM- DCs, in response to LPS stimulation. In addition, the proliferative response of stimulated alloreactive T cells was significantly decreased by morin in BM-DCs. Furthermore, allogeneic T cells secreted higher IL-4 and lower IFN-gamma in response to morin in BM- DCs. In conclusion, these results suggested that morin favors Th2 cell differentiation through modulating the maturation and function of BM-DCs. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/92621 |
顯示於: | 醫學系 |
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