Morin Promotes the Production of Th2 Cytokine by Modulating Bone Marrow- Derived Dendritic Cells
Resource
AMERICAN JOURNAL OF CHINESE MEDICINE v.34 n.4 pp.667-684
Journal
AMERICAN JOURNAL OF CHINESE MEDICINE
Journal Volume
v.34
Journal Issue
n.4
Pages
667-684
Date Issued
2006
Date
2006
Author(s)
SUEN, JAU-LING
CHIANG, BOR-LUEN
LEE, CHAO PEI-DAWN
FANG, SHIH-HUA
Abstract
Our previous studies had reported that morin decreased the interleukin-12 (IL-12) and tumor necrosis factor-alpha (TNF- alpha) production in lipopolysaccharide (LPS)-activated macrophages, suggesting that morin may promote helper T type 2 (Th2) response in vivo. Dendritic cells (DCs) are the most potent antigen presenting cells and known to play a major role in the differentiation of helper T type 1 (Th1) and Th2 responses. This study aimed to reveal whether morin is able to control the Th differentiation through modulating the maturation and functions of DCs. Bone marrow-derived dendritic cells (BM-DCs) were incubated with various concentrations of morin and their characteristics were studied. The results indicated that morin significantly affects the phenotype and cytokine expression of BM-DCs. Morin reduced the production of IL-12 and TNF-alpha in BM- DCs, in response to LPS stimulation. In addition, the proliferative response of stimulated alloreactive T cells was significantly decreased by morin in BM-DCs. Furthermore, allogeneic T cells secreted higher IL-4 and lower IFN-gamma in response to morin in BM- DCs. In conclusion, these results suggested that morin favors Th2 cell differentiation through modulating the maturation and function of BM-DCs.
Subjects
morin
dendritic cells
helper T type 1 (Th 1)
helper T type 2 (Th2)
Type
journal article