|Title:||Acute Respiratory Distress Syndrome Due to Tuberculosis in a Child after Allogenic Bone Marrow Transplantation for Acute Lymphoblastic Leukemia||Authors:||CHEN, CHIH-CHENG
|Keywords:||bone marrow transplantation;tuberculosis;Acute respiratory distress syndrome;acute lymphoblastic leukemia||Issue Date:||1999||Journal Volume:||v.98||Journal Issue:||n.10||Start page/Pages:||701-704||Source:||JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION||Abstract:||
We report the occurrence of tuberculosis in a 10-year-old Taiwanese boy, approximately 4 months after he received a matched-related bone marrow transplantation from his sister for acute T-cell lymphoblastic leukemia. After transplantation, grade III acute graft-versus-host disease developed and the patient was treated with prednisolone and cyclosporine. Marrow failure was noted on day 77 post- transplantation, however, after an episode of herpes zoster infection. Interstitial pneumonia, diagnosed on the basis of chest x-ray and computed tomography findings, occurred on day 120. Histologic examination of an open-lung biopsy specimen showed caseating granulomas and a few acid-fast bacilli. The patient died of acute respiratory distress syndrome, despite immediate implementation of antituberculosis therapy. Sputum cultures grew Mycobacterium tuberculosis 5 weeks later. This report demonstrates that the possibility of tuberculosis needs to be considered in immunocompromised patients, and that appropriate prophylaxis should be instituted in areas where tuberculosis is endemic .
|Appears in Collections:||醫學系|
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