|Title:||Serum Level of Soluble Tumor Necrosis Factor Receptor Ii (Stnf-R75) Is Apparently an Index of Overall Monocyte-Related Infectious and Inflammatory Activity||Authors:||CHIANG, BOR-LUEN
|Keywords:||receptors;tumor necrosis factor;C-reactive protein;monocytes;inflammation infection||Issue Date:||2000||Journal Volume:||v.320||Journal Issue:||n.3||Start page/Pages:||183-187||Source:||AMERICAN JOURNAL OF THE MEDICAL SCIENCES||Abstract:||
Background: The serum level of soluble tumor necrosis factor receptor II (sTNF-R75) has been recently found to correlate with the activity and/or severity of several different infectious and inflammatory diseases. These results have led us to presume that the serum sTNF-R75 level reflects the active immune activity of all causes and may correlate well with nonspecific infectious and inflammatory markers such as peripheral leukocyte counts and serum C-reactive protein level. Methods: In total, 110 apparently healthy adults, 55 men and 55 women, were enrolled in the study. Serum levels of sTNF-R75, C-reactive protein, globulin, alkaline phosphatase, lactate dehydrogenase, creatinine, urea nitrogen, and counts of neutrophils, lymphocytes, monocytes, eosinophils, and basophils were checked. The relationships between the serum sTNF-R75 level and other parameters were analyzed using the SAS statistical program. Results: By various statistical methods, the serum sTNF-R75 level showed consistently significant positive links with peripheral monocyte count, serum C- reactive protein level, and two parameters of renal clearance function ( serum urea nitrogen and creatinine levels). Serum levels of alkaline phosphatase and lactate dehydrogenase had significant positive links with the serum sTNF-R75 level by multivariate regression analysis. There was no significant link between the serum sTNF-R75 level and counts of neutrophils, lymphocytes, eosinophils, or basophils. Conclusions: Our results, together with those of recent reports showing positive correlations between the serum sTNF-R75 level and activities /severities of different infectious and inflammatory diseases, and also that TNF-alpha is principally produced by monocytes and macrophages, suggest that the serum sTNF-R75 level is very probably an index of overall monocyte-related infectious and inflammatory activities.
|Appears in Collections:||醫學系|
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